RETRA

Modify Date: 2024-04-04 13:25:43

RETRA Structure
RETRA structure
Common Name RETRA
CAS Number 1036069-26-7 Molecular Weight 269.34
Density N/A Boiling Point N/A
Molecular Formula C11H11NO3S2 Melting Point N/A
MSDS USA Flash Point N/A

 Use of RETRA


RETRA is a mutant p53-dependent activator of p73 that suppresses mutant p53-bearing cancer cells. RETRA increases the expression level of p73, and a release of p73 from the blocking complex with mutant p53, which produces tumor-suppressor effects[1].

 Names

Name 2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-(3,4-dihydroxyphenyl)ethanone,hydrochloride
Synonym More Synonyms

 RETRA Biological Activity

Description RETRA is a mutant p53-dependent activator of p73 that suppresses mutant p53-bearing cancer cells. RETRA increases the expression level of p73, and a release of p73 from the blocking complex with mutant p53, which produces tumor-suppressor effects[1].
Related Catalog
References

[1]. J E Kravchenko, et al. Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7.  

 Chemical & Physical Properties

Molecular Formula C11H11NO3S2
Molecular Weight 269.34
Exact Mass 304.99500
PSA 120.49000
LogP 2.35410

 Synonyms

RETRA hydrochloride
Reactivation of Transcriptional Reporter Activity
RETRA
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here




Get all suppliers and price by the below link:

RETRA suppliers

RETRA price