115104-28-4

115104-28-4 structure

Name: UNII:76LB1G2X6V
Chemical Name: MK 571,3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoicacid
CAS Number: 115104-28-4
Molecular Formula: C₂₆H₂₇ClN₂O₃S₂
Molecular Weight: 515.09
Catalog: Signaling Pathways GPCR/G Protein Leukotriene Receptor
Create Date: 2018-07-29 12:51:14
Modify Date: 2024-01-08 08:17:39
MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release[1][2][3].

Name	MK 571,3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoicacid
Synonyms	3-[({3-[(E)-2-(7-Chloroquinolin-2-yl)vinyl]phenyl}{[3-(dimethylamino)-3-oxopropyl]sulfanyl}methyl)sulfanyl]propanoic acid mk-571,na salt Propanoic acid, 3-[[[3-[(E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]- mk-571 sodium salt 3-[({3-[(E)-2-(7-Chloro-2-quinolinyl)vinyl]phenyl}{[3-(dimethylamino)-3-oxopropyl]sulfanyl}methyl)sulfanyl]propanoic acid mk-571 na UNII:76LB1G2X6V

Description	MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Inflammation/Immunology
Target	LTD4:0.22 nM (Ki, In guinea pig lung) LTD4:2.1 nM (Ki, In human lung) LTD4:10.5 (pA2, on guinea pig ileum) LTE4:10.4 (pA2, on guinea pig ileum)
References	[1]. Jones TR, et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D₄ receptor antagonist. Can J Physiol Pharmacol. 1989 Jan;67(1):17-28. [2]. Hara Y, et al. Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice. J Clin Invest. 2011 Jul;121(7):2888-97. [3]. Mitra P, et al. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16394-9.