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138614-30-9

138614-30-9 structure
138614-30-9 structure
  • Name: Icatibant acetate
  • Chemical Name: Icatibant acetate
  • CAS Number: 138614-30-9
  • Molecular Formula: C61H93N19O15S
  • Molecular Weight: 1364.57000
  • Catalog: Signaling Pathways GPCR/G Protein Bradykinin Receptor
  • Create Date: 2018-02-16 08:00:00
  • Modify Date: 2024-01-21 12:30:22
  • Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively[1][2][3].
Name Icatibant acetate
Synonyms Icatibant acetate
Description Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively[1][2][3].
Related Catalog
In Vitro Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3].
In Vivo Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3]. Animal Model: Female mice of the CBA/J (H-2k) strain[2]. Dosage: 0.06, 0.3, or 1.5 mg/kg. Administration: Subcutaneous administration twice daily. Result: The length of the large intestine was 93.6±6.8 mm with the 1.5 mg/kg dosage and 94.0±4.1 mm with the 0.3 mg/kg dosage , showing a significant preventive effect on shortening.
References

[1]. Hock FJ, et al. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br J Pharmacol. 1991 Mar;102(3):769-73.

[2]. Y Arai, et al. Effect of Icatibant, a Bradykinin B2 Receptor Antagonist, on the Development of Experimental Ulcerative Colitis in Mice. Dig Dis Sci. 1999 Apr;44(4):845-51.

[3]. Marie-Thérèse Bawolak, et al The Bradykinin B2 Receptor Antagonist Icatibant (Hoe 140) Blocks Aminopeptidase N at Micromolar Concentrations: Off-Target Alterations of Signaling Mediated by the Bradykinin B1 and Angiotensin Receptors. Eur J Pharmacol. 2006 Dec 3;551(1-3):108-11.
Density 1.6g/cm3
Molecular Formula C61H93N19O15S
Molecular Weight 1364.57000
Exact Mass 1363.68000
PSA 581.76000
LogP 1.67610
Storage condition -20℃
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

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title: CAS No. 138614-30-9 | Chemsrc address: https://m.chemsrc.com/en/baike/1195222.html

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