184576-87-2

184576-87-2 structure

Name: ROS 234 dioxalate
Chemical Name: ROS 234 dioxalate,N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-aminedioxalate
CAS Number: 184576-87-2
Molecular Formula: C₁₇H₁₉N₅O₈
Molecular Weight: 421.36100
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2016-08-28 00:11:57
Modify Date: 2024-01-05 11:56:42
ROS 234 is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 diaplays poor central access[1][2].

Name	ROS 234 dioxalate,N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-aminedioxalate
Synonyms	ros 234 dioxalate

Description	ROS 234 is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 diaplays poor central access[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	rat H3 receptor:8.90 (pKi)
In Vivo	ROS 234 centrally injected, significantly shortens pentobarbital narcosis[1].
References	[1]. Ballabeni V, et al. CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm Res. 2002 Apr;51 Suppl 1:S55-6. [2]. Mor M, et al. Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg Med Chem. 2004 Feb 15;12(4):663-74.