ROS 234 dioxalate

Modify Date: 2024-01-05 11:56:42

ROS 234 dioxalate Structure
ROS 234 dioxalate structure
 Common Name ROS 234 dioxalate
CAS Number 184576-87-2 Molecular Weight 421.36100
Density N/A Boiling Point N/A
Molecular Formula C17H19N5O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ROS 234 dioxalate


ROS 234 is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 diaplays poor central access[1][2].

 Names

Name ROS 234 dioxalate,N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-aminedioxalate
Synonym More Synonyms

 ROS 234 dioxalate Biological Activity

Description ROS 234 is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 diaplays poor central access[1][2].
Related Catalog
Target

rat H3 receptor:8.90 (pKi)

In Vivo ROS 234 centrally injected, significantly shortens pentobarbital narcosis[1].
References

[1]. Ballabeni V, et al. CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm Res. 2002 Apr;51 Suppl 1:S55-6.

[2]. Mor M, et al. Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg Med Chem. 2004 Feb 15;12(4):663-74.

 Chemical & Physical Properties

Molecular Formula C17H19N5O8
Molecular Weight 421.36100
Exact Mass 421.12300
PSA 218.59000
LogP 0.71490

 Synonyms

ros 234 dioxalate
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Chemsrc provides ROS 234 dioxalate(CAS#:184576-87-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ROS 234 dioxalate are included as well.>> amp version: ROS 234 dioxalate

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