DC Chemicals Limited
China
Product Name: Violacein
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: violacein
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

548-54-9

548-54-9 structure

548-54-9 structure

Name: Violacein
Chemical Name: Violacein
CAS Number: 548-54-9
Molecular Formula: C₂₀H₁₃N₃O₃
Molecular Weight: 343.34
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-05-14 08:00:00
Modify Date: 2024-01-02 16:15:46
Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer[1][2].

Name	Violacein
Synonyms	(3Z)-3-[5-(5-hydroxy-1H-indol-3-yl)-2-oxo-1H-pyrrol-3-ylidene]-1H-indol-2-one

Description	Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	Microbial Metabolite
In Vitro	Violacein (0.25-3 µM; 24h; HCT116 and HT29 cells) possesses anticancer activity in both 2D and 3D cell models[1]. Violacein decreases RTKs expression and disturbs signaling pathways in CRC cells[1]. Cell Viability Assay[1]. Cell Line: HCT116 and HT29 (1.8 × 104 cells/well-100 µL) cells. Concentration: 0.25, 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 µM. Incubation Time: 24h. Result: In the 2D culture model, the violacein treatment reduced the cell viability, since there was a decrease in formazan production in the HT29 and HCT116 cell lines. Moreover, HT29 was more sensitive to violacein, as evidenced by the IC50 value (0.6 μM) compared to HCT116 (1.2 μM).
References	[1]. Patricia F de Souza Oliveira, et al. Violacein negatively modulates the colorectal cancer survival and epithelial-mesenchymal transition. J Cell Biochem. 2022 Jul;123(7):1247-1258. [2]. Marlon Konzen, et al. Antioxidant properties of violacein: possible relation on its biological function. Bioorg Med Chem. 2006 Dec 15;14(24):8307-13.

Density	1.549g/cm3
Boiling Point	821.4ºC at 760mmHg
Molecular Formula	C₂₀H₁₃N₃O₃
Molecular Weight	343.34
Flash Point	450.6ºC
Exact Mass	343.09600
PSA	101.20000
LogP	3.11110
Index of Refraction	1.804

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%