709002-46-0
709002-46-0 structure
- Name: SirReal 2
- Chemical Name: SirReal2
- CAS Number: 709002-46-0
- Molecular Formula: C22H20N4OS2
- Molecular Weight: 420.550
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
- Create Date: 2016-08-23 21:47:29
- Modify Date: 2024-01-09 18:39:34
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SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1[1].
| Name | SirReal2 |
|---|---|
| Synonyms |
2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(1-naphthylmethyl)-1,3-thiazol-2-yl]acetamide
Acetamide, 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]- 2-[(4,6-Dimethyl-2-pyrimidinyl)sulfanyl]-N-[5-(1-naphthylmethyl)-1,3-thiazol-2-yl]acetamide |
| Description | SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1[1]. |
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| Related Catalog | |
| Target |
SIRT2:140 nM (IC50) |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C22H20N4OS2 |
| Molecular Weight | 420.550 |
| Exact Mass | 420.107849 |
| PSA | 121.31000 |
| LogP | 5.83 |
| Index of Refraction | 1.701 |
| Storage condition | -20℃ |
| RIDADR | NONH for all modes of transport |
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