681806-46-2

681806-46-2 structure

Name: BRL 44408 maleate
Chemical Name: BRL-44408 maleate
CAS Number: 681806-46-2
Molecular Formula: C₁₇H₂₁N₃O₄
Molecular Weight: 331.36600
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-04-26 01:32:02
Modify Date: 2024-01-20 07:38:20
BRL-44408 maleate is an α2A-adrenoceptor antagonist (Ki: 8.5 nM). BRL-44408 maleate has antidepressant and analgesic activity. BRL-44408 also improves cecal ligation puncture (CLP)-induced acute lung injury[1][2].

Name	BRL-44408 maleate
Synonyms	BRL44408 maleate 2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate 2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindolemaleate 2-[(2H-1-methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate BRL 44408 maleate

Description	BRL-44408 maleate is an α2A-adrenoceptor antagonist (Ki: 8.5 nM). BRL-44408 maleate has antidepressant and analgesic activity. BRL-44408 also improves cecal ligation puncture (CLP)-induced acute lung injury[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	Ki: 8.5 nM (α2A-adrenoceptor)[1]
References	[1]. Dwyer JM, et al. Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism. Int J Neuropsychopharmacol. 2010 Oct;13(9):1193-205. [2]. Cong Z, et al. α2A -AR antagonism by BRL-44408 maleate attenuates acute lung injury in rats with downregulation of ERK1/2, p38MAPK, and p65 pathway. J Cell Physiol. 2020 Oct;235(10):6905-6914.