957-66-4

957-66-4 structure

Name: Isolinderalactone
Chemical Name: (3aS,8bR)-4,8-dimethyl-3-methylene-4-vinyl-3a,4,5,8b-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one
CAS Number: 957-66-4
Molecular Formula: C₁₅H₁₆O₃
Molecular Weight: 244.29
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2018-04-09 13:55:57
Modify Date: 2025-08-25 22:04:27
Isolinderalactone suppresses human glioblastoma growth and angiogenic activity through the inhibition of VEGFR2 activation in endothelial cells[1]. Isolinderalactone suppresses the expression of B-cell lymphoma 2 (Bcl-2), survi

Name	(3aS,8bR)-4,8-dimethyl-3-methylene-4-vinyl-3a,4,5,8b-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one
Synonyms	Isolinderalactone

Description	Isolinderalactone suppresses human glioblastoma growth and angiogenic activity through the inhibition of VEGFR2 activation in endothelial cells[1]. Isolinderalactone suppresses the expression of B-cell lymphoma 2 (Bcl-2), survi
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Survivin Signaling Pathways >> Apoptosis >> IAP Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	VEGFR2 Bcl-2
References	[1]. Park JH, et al. Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models. Cancer Lett. 2020;478:71-81. [2]. Hwang JY, et al. Isolinderalactone regulates the BCL-2/caspase-3/PARP pathway and suppresses tumor growth in a human glioblastoma multiforme xenograft mouse model. Cancer Lett. 2019;443:25-33.