740841-15-0

740841-15-0 structure

Name: (E/Z)-BIO-acetoxime
Chemical Name: 6-bromoindirubin-3'-acetoxime
CAS Number: 740841-15-0
Molecular Formula: C₁₈H₁₂BrN₃O₃
Molecular Weight: 398.21000
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2018-02-10 10:34:05
Modify Date: 2024-01-08 16:40:54
(E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM)[1].

Name	6-bromoindirubin-3'-acetoxime
Synonyms	6-bromoindirubin-3'-acetoxime GSK-3 INHIBITOR X

Description	(E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM)[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	GSK-3α:10 nM (IC50) GSK-3β:10 nM (IC50) Cdk5/p25:2.4 μM (IC50) CDK2/cyclinA:4.3 μM (IC50) CDK1/cyclinB:63 μM (IC50)
In Vitro	E/Z)-BIO-acetoxime (compound 13) shows more than 200-flod selectivity for GSK-3α/β over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B, with IC50s of 0.01, 2.4, 4.3 and 63 μM, respectively[1].
References	[1]. Meijer L, et, al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10(12):1255-66.