20309-70-0

20309-70-0 structure

Name: Paeonoside
Chemical Name: paeonoside (C15 glycoside)
CAS Number: 20309-70-0
Molecular Formula: C₁₅H₂₀O₈
Molecular Weight: 328.315
Catalog: Research Areas Infection
Create Date: 2018-05-20 19:33:51
Modify Date: 2024-01-08 18:04:38
Paeonoside is a bioactive compound identified in P. suffruticosa that promotes wound healing and migration in osteoblast differentiation. Paeonoside has also been reported to have some antidiabetic activity and may prevent sepsis-induced lethality[1].

Name	paeonoside (C15 glycoside)
Synonyms	2-Acetyl-5-methoxyphenyl beta-D-Glucopyranoside (2-Acetyl-5-methoxy-phenyl)-β-D-glucopyranosid 2-Acetyl-5-methoxyphenyl β-D-glucopyranoside Ethanone, 1-[2-(β-D-glucopyranosyloxy)-4-methoxyphenyl]- paeonoside (2-acetyl-5-methoxy-phenyl)-β-D-glucopyranoside glucopaeonol Resacetophenon-4-O-methyl-2-β-D-glucosid

Description	Paeonoside is a bioactive compound identified in P. suffruticosa that promotes wound healing and migration in osteoblast differentiation. Paeonoside has also been reported to have some antidiabetic activity and may prevent sepsis-induced lethality[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
In Vitro	Paeonoside (PASI) (0.1-100 μM, 24 h) has no cytotoxic effect on pro-osteoblasts of MC3T3-E1 cells[1]. Paeonoside (PASI) (1-30 μM, 24 h) can significantly restore wound areas and promote cell migration in a dose-dependent manner during the induction of preosteoblast of MC3T3-E1 cells differentiation using osteogenic supplement (OS) medium. In parallel, PASI promotes alkaline phosphatase (ALP) staining and its activity in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: Pro-osteoblasts of MC3T3-E1 cells Concentration: 1-10 μM Incubation Time: 24 h Result: Increased the expression of BMP2 and Wnt3a, stimulated Smad1/5/8 phosphorylation, GSK3β phosphorylation and β-linked protein expression as well as upregulated RUNX2 expression.