5250-39-5

• 常用中文名：氟氯西林
• 常用英文名：Flucloxacillin
• CAS号：5250-39-5
• 分子式：C₁₉H₁₇ClFN₃O₅S
• 分子量：453.872
• 相关类别： 原料药 抗生素类药物 青霉素类药
• 发布时间：2018-02-13 08:00:00
• 更新时间：2026-07-11 19:48:35
• 氟氯西林是一种抗革兰氏阳性和革兰氏阴性细菌的活性抗生素[1][2]。

名称

• 中文名: 氟氯西林
• 英文名: flucloxacillin
• 中文别名: 氟氧苯唑青霉素; 氟氯苯唑青霉素; 福氯平; 氟氯唑西林杂质; (2S,5R,6R)-6-[[3-(2-氯-6-氟苯基)-5-甲基-1,2-恶唑-4-甲酰]氨基]-3,3-二甲基-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-羧酸; (2S,5R,6R)-6-(3-(2-氯-6-氟苯基)-5-甲基异噁唑-4-甲酰胺基)-3,3-二甲基-7-氧代-4-噻吩-1-氮杂双环[ 3.2.0]庚烷-2-羧酸 (氯唑西林杂质); 氟氯西林酸; 氟氯青霉素
• 英文别名: (2S,5R,6R)-6-[[3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid; (2S,5R,6R)-6-[[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]amino]-7-keto-3,3-dimethyl-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid; Floxapen; Phenylbutazone Impurity 34; Culpen; (2S,5R,6R)-6-({[3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Fluoxacillin; EINECS 226-051-0; Flucil; Flucloxacillin //BP; 6-[3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolecboxamido]penicillanic acid; 6-[3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolecboxamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid; Ladropen; MFCD00864886; Fluchlxacillin; Floxacillin; 4-Thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid, 6-[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecboxamido]-3,3-dimethyl-7-oxo- (8CI); Penplus; Stafoxil; [3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]penicillin; BRL 2039; Flucloxcillin; 4-Thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid, 6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R); Flopen; (2S,5R,6R)-6-({[3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Abboflox; FLUCLOXACILLIN; 4-Thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid, 6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, [2S-(2α,5α,6β)]; (2S,5R,6R)-6-(3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-cboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid (Cloxacillin Impurity); FLOXACILLIN; (2S,5R,6R)-6-[[3-(2-chloro-6-fluoro-phenyl)-5-methyl-1,2-oxazol-4-yl]cbonylamino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid; Flupen; Staphcil; Staphylex; Staphlipen; FK 900

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 677.3±55.0 °C at 760 mmHg
• 分子式: C₁₉H₁₇ClFN₃O₅S
• 分子量: 453.872
• 闪点: 363.4±31.5 °C
• 精确质量: 453.056152
• PSA: 138.04000
• LogP: 2.60
• 外观性状: 白色至灰白色自由流动结晶粉末
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.672

生物活性

• 描述: 氟氯西林是一种抗革兰氏阳性和革兰氏阴性细菌的活性抗生素[1][2]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体内研究: 氟氯西林(200 mg/kg；静脉注射；每天三次,共21天；雄性Wistar大鼠)对假体周围感染中最常见的细菌株有效[1]。动物模型：雄性Wistar大鼠[1]剂量：200mg/kg给药：腹腔注射；每天三次,持续21天结果：生物膜和骨组织中的细菌减少。
• 参考文献:

  [1]. Greimel F, et, al. Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study. Drug Des Devel Ther. 2017 Jun 14;11:1729-1736.

  [2]. Comber KR, Merrikin DJ, Sutherland R. Antibacterial activity and synergy, in vitro and in vivo, of a combination of amoxycillin and flucloxacillin. Chemotherapy. 1979;25(1):30-9.