- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Lobetyolin
- Price: Check
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Lobetyolin
- Price: ￥818.0/10mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- DC Chemicals Limited
- China
- Product Name: Lobetyolin
- Price: $280.0/20mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
136085-37-5
136085-37-5 structure
- Name: Lobetyolin
- Chemical Name: Lobetyolin
- CAS Number: 136085-37-5
- Molecular Formula: C20H28O8
- Molecular Weight: 396.431
- Catalog: Biochemical Plant extracts
- Create Date: 2018-06-12 12:07:14
- Modify Date: 2025-08-20 18:03:50
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Lobetyolin is derived from Codonopsis pilosula and has antioxidative effect.
| Name | Lobetyolin |
|---|---|
| Synonyms |
(4E,12E)-1,7-Dihydroxy-4,12-tetradecadiene-8,10-diyn-6-yl β-D-glucopyranoside
(4E,12E)-1,7-Dihydroxytetradeca-4,12-diene-8,10-diyn-6-yl β-D-glucopyranoside β-D-Glucopyranoside, (7E)-2-hydroxy-1-[(1E)-5-hydroxy-1-penten-1-yl]-7-nonene-3,5-diyn-1-yl (2R,3R,4S,5S,6R)-2-[(4E,12E)-1,7-dihydroxytetradeca-4,12-dien-8,10-diyn-6-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol |
| Description | Lobetyolin is derived from Codonopsis pilosula and has antioxidative effect. |
|---|---|
| Related Catalog | |
| In Vitro | Lobetyolin is derived from Codonopsis pilosula and has antioxidative effect. MUC5AC gene expression induced by phorbol 12-myristate 13-acetate (PMA) from NCI-H292 cells is inhibited by pretreatment with Lobetyolin, lobetyol or methyl linoleate. Lobetyolin does not affect PMA-induced MUC5AC production from NCI-H292 cells. The amounts of mucin in the cells of Lobetyolin-treated cultures are 100±25%, 487±33%, 524±38%, 411±24%, and 402±45% for control, 10 ng/mL of PMA alone, PMA plus Lobetyolin 1 μM, PMA plus Lobetyolin 10 μM, and PMA plus Lobetyolin 100 μM, respectively[1]. |
| Cell Assay | After 24 hours of serum deprivation, cells are pretreated with Lobetyolin, lobetyol or methyl linoleate (1, 10, and 100 µM), for 30 minutes and then treated with phorbol 12-myristate 13-acetate (PMA; 10 ng/mL) for 24 hours in serum-free RPMI 1640. After 24 hours, the spent media are collected to measure the secretion of MUC5AC protein and cells are lysed with buffer solution containing 20 mM Tris, 0.5% NP-40, 250 mM NaCl, 3 mM EDTA, 3 mM EGTA, and protease inhibitor cocktail and collected to measure the production of MUC5AC protein (in 24-well culture plate)[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 698.5±55.0 °C at 760 mmHg |
| Molecular Formula | C20H28O8 |
| Molecular Weight | 396.431 |
| Flash Point | 376.2±31.5 °C |
| Exact Mass | 396.178406 |
| PSA | 139.84000 |
| LogP | 2.02 |
| Vapour Pressure | 0.0±5.0 mmHg at 25°C |
| Index of Refraction | 1.607 |