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24211-30-1

24211-30-1 structure
24211-30-1 structure
  • Name: Farrerol
  • Chemical Name: 5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-2,3-dihydrochromen-4-one
  • CAS Number: 24211-30-1
  • Molecular Formula: C17H16O5
  • Molecular Weight: 300.306
  • Catalog: API Respiratory medication Antitussive
  • Create Date: 2018-07-05 17:51:31
  • Modify Date: 2025-08-25 17:35:02
  • Farrerol is a bioactive constituent of Rhododendron, with broad activities such as anti-oxidative, anti-inflammatory, anti-tumor, neuroprotective and hepatoprotective effects[1][2][3][4][5][6].
Name 5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-2,3-dihydrochromen-4-one
Synonyms EINECS 246-080-2
4',5,7-Trihydroxy-6,8-dimethylflavanone
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-
Farrerol
5,7-Dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethylchroman-4-one
5,7-Dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-2,3-dihydro-4H-chromen-4-one
Farresol
Cyrtopterinetin
6,8-dimethyl-5,7,4'-trihydroxyflavanone
MFCD00017315
matteucinol
Description Farrerol is a bioactive constituent of Rhododendron, with broad activities such as anti-oxidative, anti-inflammatory, anti-tumor, neuroprotective and hepatoprotective effects[1][2][3][4][5][6].
Related Catalog
In Vitro Farrerol observably reduces the production of inflammatory mediators including IL-1β, IL-6, TNF-α, COX-2, and iNOS in LPS-induced RAW264.7 cells via suppressing AKT, ERK1/2, JNK1/2, and NF-κB p65 phosphorylation[1]. Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line[2]. Farrerol inhibits angiogenesis through Akt/mTOR, Erk and Jak2/Stat3 signal pathway[3]. Farrerol overcomes the invasiveness of lung squamous cell carcinoma cells by regulating the expression of inducers of epithelial mesenchymal transition[4]. Farrerol ameliorates acetaminophen-induced hepatotoxicity via activation of Nrf2 and autophagy[6].
In Vivo Farrerol protects dopaminergic neurons in a rat model of lipopolysaccharide-induced Parkinson's disease by suppressing the activation of the AKT and NF-κB signaling pathways[5].
References

[1]. Ran X, et al. Farrerol Ameliorates TNBS-Induced Colonic Inflammation by Inhibiting ERK1/2, JNK1/2, and NF-κB Signaling Pathway. Int J Mol Sci. 2018 Jul 13;19(7).

[2]. Cui B, et al. Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line. Biomed Pharmacother. 2019 Jan;109:112-119.

[3]. Dai F, et al. Farrerol inhibited angiogenesis through Akt/mTOR, Erk and Jak2/Stat3 signal pathway. Phytomedicine. 2016 Jun 15;23(7):686-93.

[4]. Li B, et al. Farrerol overcomes the invasiveness of lung squamous cell carcinoma cells by regulating the expression of inducers of epithelial mesenchymal transition. Microb Pathog. 2019 Jun;131:277.

[5]. Li Y, et al. Farrerol protects dopaminergic neurons in a rat model of lipopolysaccharide-induced Parkinson's disease by suppressing the activation of the AKT and NF-κB signaling pathways. Int Immunopharmacol. 2019 Oct;75:105739.

[6]. Wang L, et al. Farrerol Ameliorates APAP-induced Hepatotoxicity via Activation of Nrf2 and Autophagy. Int J Biol Sci. 2019 Jan 29;15(4):788-799.
Density 1.4±0.1 g/cm3
Boiling Point 583.0±50.0 °C at 760 mmHg
Molecular Formula C17H16O5
Molecular Weight 300.306
Flash Point 219.7±23.6 °C
Exact Mass 300.099762
PSA 86.99000
LogP 4.11
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.662
Storage condition 2~8℃
Hazard Codes Xi
RIDADR NONH for all modes of transport
HS Code 2932999099
HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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