24211-30-1

• 常用中文名：杜鹃素
• 常用英文名：Farrerol
• CAS号：24211-30-1
• 分子式：C₁₇H₁₆O₅
• 分子量：300.306
• 相关类别： 原料药 呼吸系统用药 镇咳药
• 发布时间：2018-07-05 17:51:31
• 更新时间：2026-06-30 17:28:33
• Farrerol 是杜鹃花的一种生物活性成分,具有抗氧化、抗炎、抗肿瘤、神经保护和肝保护等多种作用。

名称

• 中文名: 杜鹃素
• 英文名: 5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-2,3-dihydrochromen-4-one
• 中文别名: 杜鹃素,10 MM DMSO 溶液; 杜鹃素对照品; 4-羟基苯基-6,8-二甲基-2,3-二氢苯并吡喃-4-酮; 杜鹃素 Solbio/索莱宝 IF0420; (S)-5,7-二羟基-2-(4-羟基苯基)-6,8-二甲基苯并二氢吡喃-4-酮; 5,7-二羟基-2-(4-羟基苯基)-6,8-二甲基-2,3-二氢苯并吡喃-4-酮; 法尔杜鹃素; 杜鹃素/HPLC; 法尔杜鹃素,5,7-二羟基-2; 杜鹃素, 来源于杜鹃; Frerol #天然产物 HY-N0344; 杜鹃素(法尔杜鹃素,5,7-二羟基-2-(4-羟基苯基)-6,8-二甲基-2,3-二氢苯并吡喃-4-酮); FREROL 杜鹃素; 杜鹃素(标准品)
• 英文别名: 5,7,4'-TRIHYDROXY-6,8-DIMETHYLFLAVANONE; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-, (2S); FREROL; 5,7,4'-Trihydroxy-6,8-Dimethoxyflavanone; (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-2,3-dihydrochromen-4-one; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-2,3-dihydro-4H-chromen-4-one; MFCD00017315; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6,8-diMethylchroMan-4-one; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-2,3-dihydrochromen-4-one; 6,8-DIMETHYL-4',5,7-TRIHYDROXYFLAVANONE //BP; EINECS 246-080-2; 5,7-Dihydroxy-2-(4-hydroxyphenyl); (2S)-6,8-Dimethyl-4',5,7-trihydroxyflavanone; 6,8-DIMETHYL-5,7,4'-TRIHYDROXYFLAVANONE; (S)-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-4-benzopyrone; Frerol from Rhododendron simsii Planch; CYRTOPTERINETIN(RG); (2S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-4H-1-benzopyran-4-one; Frerol, 10 mM in DMSO; 6,8-DIMETHYL-4',5,7-TRIHYDROXYFLAVANONE; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethylchroman-4-one; Farresol; (-)-Frerol; Cyrtopterinetin; CYRTPOTERINETIN; CYRTOPTERINETIN; (S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethylchroman-4-one; 4',5,7-Trihydroxy-6,8-dimethylflavanone; Frerol >= (HPLC); 6,8-dimethylchroman-4-one; 6,8-dimethyl-5,7,4'-trihydroxyflavanone; matteucinol

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 583.0±50.0 °C at 760 mmHg
• 分子式: C₁₇H₁₆O₅
• 分子量: 300.306
• 闪点: 219.7±23.6 °C
• 精确质量: 300.099762
• PSA: 86.99000
• LogP: 4.11
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.662
• 储存条件: 2~8℃

生物活性

• 描述: Farrerol 是杜鹃花的一种生物活性成分,具有抗氧化、抗炎、抗肿瘤、神经保护和肝保护等多种作用。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 体外研究: Farrerol通过抑制AKT,ERK1/2,JNK1/2和NF-κB,可显着减少LPS诱导的RAW264.7细胞中炎症介质(包括IL-1β,IL-6,TNF-α,COX-2和iNOS)的产生。p65磷酸化[1]。Farrerol通过小胶质细胞系中的Nrf2/Keap1途径减弱β-淀粉样蛋白诱导的氧化应激和炎症[2]。Farrerol通过Akt/mTOR,Erk和Jak2/Stat3信号通路抑制血管生成[3]。Farrerol通过调节上皮-间质转化诱导剂的表达克服了肺鳞状细胞癌细胞的侵袭性[4]。Farrerol通过激活Nrf2和自噬改善对乙酰氨基酚诱导的肝毒性[6]。
• 体内研究: Farrerol通过抑制AKT和NF-κB信号通路的激活来保护脂多糖诱导的帕金森病大鼠模型中的多巴胺能神经元[5]。
• 参考文献:

  [1]. Ran X, et al. Farrerol Ameliorates TNBS-Induced Colonic Inflammation by Inhibiting ERK1/2, JNK1/2, and NF-κB Signaling Pathway. Int J Mol Sci. 2018 Jul 13;19(7).

  [2]. Cui B, et al. Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line. Biomed Pharmacother. 2019 Jan;109:112-119.

  [3]. Dai F, et al. Farrerol inhibited angiogenesis through Akt/mTOR, Erk and Jak2/Stat3 signal pathway. Phytomedicine. 2016 Jun 15;23(7):686-93.

  [4]. Li B, et al. Farrerol overcomes the invasiveness of lung squamous cell carcinoma cells by regulating the expression of inducers of epithelial mesenchymal transition. Microb Pathog. 2019 Jun;131:277.

  [5]. Li Y, et al. Farrerol protects dopaminergic neurons in a rat model of lipopolysaccharide-induced Parkinson's disease by suppressing the activation of the AKT and NF-κB signaling pathways. Int Immunopharmacol. 2019 Oct;75:105739.

  [6]. Wang L, et al. Farrerol Ameliorates APAP-induced Hepatotoxicity via Activation of Nrf2 and Autophagy. Int J Biol Sci. 2019 Jan 29;15(4):788-799.

安全

• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2932999099

海关

海关编码	2932999099
中文概述	2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%