97792-45-5
97792-45-5 structure
- Name: Lappaconitine Hydrobromide
- Chemical Name: Lappaconitine Hydrobromide
- CAS Number: 97792-45-5
- Molecular Formula: C32H45BrN2O8
- Molecular Weight: 665.612
- Catalog: API Antipyretic analgesics Analgesic
- Create Date: 2018-06-12 09:52:15
- Modify Date: 2026-07-23 20:07:55
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Lappaconitine hydrobromide, a diterpene alkaloid, is a drug for the treatment of cardiac arrhythmias.IC50 value:Target: A natural product for anti-cardiac arrhythmiasIn vitro: Lappaconitine hydrobromide was found to exert an inhibitory effect on inward tetrodotoxin-sensitive sodium currents without changing their voltage dependence [1]. In vivo: The effect of Lappaconitine hydrobromide on aconitine--induced arrhythmias is due to modulation of genes encoding Na(+)-, K(+)-, Ca(2+)-channels, conducting ionic currents (I(Na), I(to), I(Ks), I(K1), I(CaT)), which are involved in the formation of different phases of the action potential [2]. Lappaconitine hydrobromide was found to be beneficial both in ventricular and supraventricular premature beats. Oral allapinine usually showed its effect 40-60 minutes following its administration, its maximum action being 4-5 hours later, its duration was some 8 hours. The optimal dose of the drug amounted to 75 mg/day [3].
| Name | Lappaconitine Hydrobromide |
|---|---|
| Synonyms |
(1α,14α,16β)-20-Ethyl-8,9-dihydroxy-1,14,16-trimethoxyaconitan-4-yl 2-acetamidobenzoate hydrobromide (1:1)
(1a,14a,16b)-20-Ethyl-1,14,16-trimethyoxyaconitane-4,8,9-triol 4-(2-(Acetylamino)benzoate) Monohydrobromide lappaconitine hydrobromide Lappaconit Hydrobromide Lappaconitine Hydrobromide 97-5 Lannaconitine Hydrobromide 1a, 14a, 16a,-4-(2-Acetylaminobenzoyloxy)-1, 14,16-Trimethyoxy-20-ethylaconitane-8,9-diol, hydrobromide LAPPACONITINE HYDROBROMIDE //BP Lappaconite Hydrobromide LAPPACONITINE HYDROB Lappaconitine Hydrobromide Monohydrate Benzoic acid, 2-(acetylamino)-, (1α,14α,16β)-20-ethyl-8,9-dihydroxy-1,14,16-trimethoxyaconitan-4-yl ester, hydrobromide (1:1) Lappaconitine hcl Lappaconitine hydrobromide, 10 mM in DMSO (1α,14α,16Β)-20-Ethyl-8,9-dihydroxy-1,14,16-trimethoxyaconitan-4-yl 2-acetamidobe lappaconitihydrobromidum appaconitine hydrobromide LAPPACONITINE(P) //BP Aconitane-4,8,9-triol, 20-ethyl-1,14,16-trimethoxy-,4-[2-(acetylamino)benzoate], monohydrobromide, (1a,14a,16b) Aconitane-4,8,9-triol, 20-ethyl-1,14,16-trimethoxy-, 4-[2-(acetylamino)benzoate], hydrobromide (1:1), (1α,14α,16β) LAPPACONITINE HBR ALLAPININE HYDROBROMIDE LAPPCONIFINEHYDROBROIDE (1α,14α,16β)-20-ethyl-8,9-dihydroxy-1,14,16-trimethoxyaconitan-4-yl 2-(acetylamino)benzoate hydrobromide (1:1) Lappaconite HBr 97-5 C32H45BrN2O8 LAPPACONITINE HYDROBROMIDE allapinin Lappaconitine Hydrobromide > Lappaconitine Hydrobromide And Glucose Injection ALLAPININE (1a,14a,16b)-20-Ethyl-1,14,16-trimethoxyaconitane-4,8,9-triol 4-(2-(acetylamino)benzoate) hydrobromide LAPPACONITINE HYDROBROMIDE (1-alpha,14-alpha,16-beta)-monohydrobromide |
| Description | Lappaconitine hydrobromide, a diterpene alkaloid, is a drug for the treatment of cardiac arrhythmias.IC50 value:Target: A natural product for anti-cardiac arrhythmiasIn vitro: Lappaconitine hydrobromide was found to exert an inhibitory effect on inward tetrodotoxin-sensitive sodium currents without changing their voltage dependence [1]. In vivo: The effect of Lappaconitine hydrobromide on aconitine--induced arrhythmias is due to modulation of genes encoding Na(+)-, K(+)-, Ca(2+)-channels, conducting ionic currents (I(Na), I(to), I(Ks), I(K1), I(CaT)), which are involved in the formation of different phases of the action potential [2]. Lappaconitine hydrobromide was found to be beneficial both in ventricular and supraventricular premature beats. Oral allapinine usually showed its effect 40-60 minutes following its administration, its maximum action being 4-5 hours later, its duration was some 8 hours. The optimal dose of the drug amounted to 75 mg/day [3]. |
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| Related Catalog | |
| References |
| Boiling Point | 740.8ºC at 760 mmHg |
|---|---|
| Melting Point | 223-226ºC |
| Molecular Formula | C32H45BrN2O8 |
| Molecular Weight | 665.612 |
| Flash Point | 401.8ºC |
| Exact Mass | 664.235901 |
| PSA | 126.79000 |
| LogP | 3.19060 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | T+: Very toxic; |
|---|---|
| Risk Phrases | R28 |
| Safety Phrases | 45 |
| RIDADR | UN 1544 6.1/PG 2 |
| RTECS | AR5569600 |
| Packaging Group | II |
| HS Code | 29399990 |