33008-99-0

33008-99-0 structure

Name: 5'-Phosphoguanylyl-(3',5')-guanosine
Chemical Name: 5'-phosphoguanylyl-(3'->5')-guanosine
CAS Number: 33008-99-0
Molecular Formula: C₂₀H₂₆N₁₀O₁₅P₂
Molecular Weight: 708.42600
Catalog: Research Areas Metabolic Disease
Create Date: 2018-02-10 16:24:59
Modify Date: 2024-01-16 12:24:23
5'-Phosphoguanylyl-(3',5')-guanosine (pGpG) is an intermediate molecule produced by the pathway for enzymatic cyclic diguanylate (c-di-GMP) degradation. 5'-Phosphoguanylyl-(3',5')-guanosine can be used to detect the metabolism of nucleic acids[1][2].

Name	5'-phosphoguanylyl-(3'->5')-guanosine
Synonyms	pG3'p5'G pG3'pG guanylyl-(5'->3')-[5']guanylic acid Guanylyl(3'->5')guanin

Description	5'-Phosphoguanylyl-(3',5')-guanosine (pGpG) is an intermediate molecule produced by the pathway for enzymatic cyclic diguanylate (c-di-GMP) degradation. 5'-Phosphoguanylyl-(3',5')-guanosine can be used to detect the metabolism of nucleic acids[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	5'-Phosphoguanylyl-(3',5')-guanosine reduces the rate of c-di-GMP degradation in cell lysates and inhibits the activity of EAL-dependent PDEs (PA2133, PvrR, and purified recombinant RocR) from P. aeruginosa[2].
References	[1]. Nesbitt NM, et, al. Modification of a bi-functional diguanylate cyclase-phosphodiesterase to efficiently produce cyclic diguanylate monophosphate. Biotechnol Rep (Amst). 2015 May 5;7:30-37. [2]. Cohen D, et, al. Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11359-64.