35874-49-8

35874-49-8 structure

Name: 8-NH2-ATP
Chemical Name: 8-amino-O5'-tetrahydroxy[1]triphosphoryl-adenosine
CAS Number: 35874-49-8
Molecular Formula: C₁₀H₁₇N₆O₁₃P₃
Molecular Weight: 522.19600
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2018-04-20 05:33:54
Modify Date: 2024-01-08 07:44:26
8-NH2-ATP, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado is reported to be potent as shown by induction of apoptosis-related cleavage of poly (ADP-ribose) polymerase[1][2].

Name	8-amino-O5'-tetrahydroxy[1]triphosphoryl-adenosine
Synonyms	8-Amino-ATP Amino-8-ATP 8-AMINOADENOSINE-5'-O-TRIPHOSPHATE

Description	8-NH2-ATP, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado is reported to be potent as shown by induction of apoptosis-related cleavage of poly (ADP-ribose) polymerase[1][2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Metabolic Disease
In Vitro	The extensive cellular accumulation of 8-NH2-ATP has an inhibitory effect on both RNA and DNA synthesis in both glucocorticoid-sensitive and glucocorticoid-resistant myeloma cell lines[1][2].
References	[1]. Nancy L Krett, et al. 8-amino-adenosine is a potential therapeutic agent for multiple myeloma. Mol Cancer Ther. 2004 Nov;3(11):1411-20. [2]. Yuji Matsuzaki, et al. ATP-association to intrabacterial nanotransportation system in Vibrio cholera. Med Mol Morphol. 2015 Dec;48(4):225-34.