8-NH2-ATP

Modify Date: 2024-01-08 07:44:26

8-NH2-ATP Structure
8-NH2-ATP structure
Common Name 8-NH2-ATP
CAS Number 35874-49-8 Molecular Weight 522.19600
Density N/A Boiling Point N/A
Molecular Formula C10H17N6O13P3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 8-NH2-ATP


8-NH2-ATP, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado is reported to be potent as shown by induction of apoptosis-related cleavage of poly (ADP-ribose) polymerase[1][2].

 Names

Name 8-amino-O5'-tetrahydroxy[1]triphosphoryl-adenosine
Synonym More Synonyms

 8-NH2-ATP Biological Activity

Description 8-NH2-ATP, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado is reported to be potent as shown by induction of apoptosis-related cleavage of poly (ADP-ribose) polymerase[1][2].
Related Catalog
In Vitro The extensive cellular accumulation of 8-NH2-ATP has an inhibitory effect on both RNA and DNA synthesis in both glucocorticoid-sensitive and glucocorticoid-resistant myeloma cell lines[1][2].
References

[1]. Nancy L Krett, et al. 8-amino-adenosine is a potential therapeutic agent for multiple myeloma. Mol Cancer Ther. 2004 Nov;3(11):1411-20.

[2]. Yuji Matsuzaki, et al. ATP-association to intrabacterial nanotransportation system in Vibrio cholera. Med Mol Morphol. 2015 Dec;48(4):225-34.

 Chemical & Physical Properties

Molecular Formula C10H17N6O13P3
Molecular Weight 522.19600
Exact Mass 522.00700
PSA 334.58000

 Synonyms

8-Amino-ATP
Amino-8-ATP
8-AMINOADENOSINE-5'-O-TRIPHOSPHATE