64872-76-0
64872-76-0 structure
- Name: Butoconazole
- Chemical Name: butoconazole
- CAS Number: 64872-76-0
- Molecular Formula: C19H17Cl3N2S
- Molecular Weight: 411.776
- Catalog: API Synthetic anti-infective drugs Antifungal drugs
- Create Date: 2018-09-10 02:27:18
- Modify Date: 2024-01-02 17:02:47
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Butoconazole, an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole is presumed to function as other imidazole derivatives via inhibition of steroid synthesis[1][2].
| Name | butoconazole |
|---|---|
| Synonyms |
BUTONAZOLE
1-{4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl}-1H-imidazole 1-[2-(2,6-dichlorophenylthio)-4-(4-chlorophenyl)-n-butyl]imidazole Butoconazole 1-[4-(4-chloro-phenyl)-2-(2,6-dichloro-phenylsulfanyl)-butyl]-1H-imidazole 1H-Imidazole, 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]- Butooonazole (+/-)-1-[4-(4-chlorophenyl)-2[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenyl)sulfanyl-butyl]imidazole 1-[2-(2,6-dichlorophenylthio)-4-(4-chlorophenyl)butyl]imidazole 1-[2-[(2,6-Dichlorophenyl)thio]-4-(4-chlorophenyl)butyl]-1H-imidazole (±)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole Gynomyk MFCD00865616 exelgyn |
| Description | Butoconazole, an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole is presumed to function as other imidazole derivatives via inhibition of steroid synthesis[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Imidazoles generally inhibit the conversion of lanosterol to ergosterol, resulting in a change in fungal cell membrane lipid composition. This structural change alters cell permeability and, ultimately, results in the osmotic disruption or growth inhibition of the fungal cell[1]. |
| References |
[2]. Pharmacology refers to the chemical makeup and behavior of GYNAZOLE 1 (butoconazole nitrate cream). |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 566.9±50.0 °C at 760 mmHg |
| Melting Point | 68-70.5ºC |
| Molecular Formula | C19H17Cl3N2S |
| Molecular Weight | 411.776 |
| Flash Point | 296.7±30.1 °C |
| Exact Mass | 410.017792 |
| PSA | 43.12000 |
| LogP | 6.88 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.634 |
| Storage condition | -20℃ |
| Hazard Codes | C |
|---|---|
| Risk Phrases | R14:Reacts violently with water. R34:Causes burns. R40:Limited evidence of a carcinogenic effect. R42/43:May cause sensitization by inhalation and skin contact . |
| Safety Phrases | S22-S26-S36/37/39-S45 |
| RIDADR | UN 3260 8/PG 2 |
| WGK Germany | 3 |
| Packaging Group | II |
| Hazard Class | 8 |
| HS Code | 2933290090 |
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |