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27219-07-4

27219-07-4 structure
27219-07-4 structure
  • Name: Boc-NH-C4-acid
  • Chemical Name: 5-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid
  • CAS Number: 27219-07-4
  • Molecular Formula: C10H19NO4
  • Molecular Weight: 217.262
  • Catalog: Biochemical Amino acids and their derivatives BOC-amino acid
  • Create Date: 2018-07-05 14:31:34
  • Modify Date: 2025-08-26 10:33:32
  • Boc-NH-C4-acid is a PROTAC linker, which belongs to a Alkyl/ether linker. Boc-NH-C4-acid can be used in the synthesis of the compound PROTAC1, and specifically degrades EED, EZH2, and SUZ12 in the PRC2 Complex.
Name 5-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid
Synonyms 5-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)pentanoic acid
5-[(tert-Butoxycarbonyl)amino]pentanoic acid
5-(N-t-butoxycarbonylamino)pentanoic acid
5-[[(1,1-Dimethylethoxy)carbonyl]amino]-pentanoic acid
MFCD00076903
5-[(tert-Butoxycarbonyl)amino]valeric Acid
5-(Boc-amino)valeric acid
Boc-5-Ava-OH
N-(tert-Butoxycarbonyl)-5-aminovaleric Acid
2-Methyl-2-propanyl 6-hydroxy-6-oxonorleucinate
Hexanedioic acid, 2-amino-, 1-(1,1-dimethylethyl) ester
5-(Boc-amino)pentanoic Acid
5-(tert-Butoxycarbonylamino)pentanoic Acid
5-(N-Boc-amino)valeric acid
N-Boc-5-aminovaleric Acid
5-Boc-amino-pentanoic acid
5-(tert-Butoxycarbonylamino)valeric Acid
N-Boc-5-aminopentanoic Acid
5-(N-t-butoxycarbonylamino)valeric acid
Pentanoic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-
boc-5-aminovaleric acid
5-(N-tert-butoxycarbonylamino)-pentanoic acid
5-(N-t-butyloxycarbonylamino)-pentanoic acid
N-(tert-Butoxycarbonyl)-5-aminopentanoic Acid
Boc-5-aminopentanoic acid
Description Boc-NH-C4-acid is a PROTAC linker, which belongs to a Alkyl/ether linker. Boc-NH-C4-acid can be used in the synthesis of the compound PROTAC1, and specifically degrades EED, EZH2, and SUZ12 in the PRC2 Complex.
Related Catalog
Target

Alkyl/ether

References

[1]. [1].Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.
Density 1.1±0.1 g/cm3
Boiling Point 331.7±27.0 °C at 760 mmHg
Melting Point 48-52 °C(lit.)
Molecular Formula C10H19NO4
Molecular Weight 217.262
Flash Point 154.4±23.7 °C
Exact Mass 217.131409
PSA 75.63000
LogP 0.84
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.475
Storage condition 2-8°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2924199090
24424-99-5 structure

24424-99-5

660-88-8 structure

660-88-8

~95%

27219-07-4 structure

27219-07-4

Literature: Gavande, Navnath; Kim, Hye-Lim; Doddareddy, Munikumar R.; Johnston, Graham A. R.; Chebib, Mary; Hanrahan, Jane R. ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 4 p. 402 - 407
74651-77-7 structure

74651-77-7

660-88-8 structure

660-88-8

~47%

27219-07-4 structure

27219-07-4

Literature: Lippard, Stephen J.; Barnes, Carmen M.; Haskel, Ariel; Barnes, Katie R. Patent: US2004/235712 A1, 2004 ; Location in patent: Page/Page column 34 ;
85908-96-9 structure

85908-96-9

~90%

27219-07-4 structure

27219-07-4

Literature: Flynn, Daniel L.; Zelle, Robert E.; Grieco, Paul A. Journal of Organic Chemistry, 1983 , vol. 48, # 14 p. 2424 - 2426
34619-03-9 structure

34619-03-9

660-88-8 structure

660-88-8

~75%

27219-07-4 structure

27219-07-4

Literature: Hartlieb, Matthias; Pretzel, David; Kempe, Kristian; Fritzsche, Carolin; Paulus, Renzo M.; Gottschaldt, Michael; Schubert, Ulrich S. Soft Matter, 2013 , vol. 9, # 18 p. 4693 - 4704
41840-28-2 structure

41840-28-2

660-88-8 structure

660-88-8

~94%

27219-07-4 structure

27219-07-4

Literature: Ishida, Hideharu; Ogawa, Yuji; Imai, Yasuyuki; Kiso, Makoto; Hasegawa, Akira; et al. Carbohydrate Research, 1989 , vol. 194, p. 199 - 208
24424-99-5 structure

24424-99-5

497-19-8 structure

497-19-8

660-88-8 structure

660-88-8

~%

27219-07-4 structure

27219-07-4

Literature: Nisshin Flour Milling Co., Ltd. Patent: US6252041 B1, 2001 ;
675-20-7 structure

675-20-7

~%

27219-07-4 structure

27219-07-4

Literature: Flynn, Daniel L.; Zelle, Robert E.; Grieco, Paul A. Journal of Organic Chemistry, 1983 , vol. 48, # 14 p. 2424 - 2426
24424-99-5 structure

24424-99-5

~%

27219-07-4 structure

27219-07-4

Literature: Flynn, Daniel L.; Zelle, Robert E.; Grieco, Paul A. Journal of Organic Chemistry, 1983 , vol. 48, # 14 p. 2424 - 2426
HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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