Boc-NH-C4-acid

Modify Date: 2024-01-09 17:03:16

Boc-NH-C4-acid Structure
Boc-NH-C4-acid structure
Common Name Boc-NH-C4-acid
CAS Number 27219-07-4 Molecular Weight 217.262
Density 1.1±0.1 g/cm3 Boiling Point 331.7±27.0 °C at 760 mmHg
Molecular Formula C10H19NO4 Melting Point 48-52 °C(lit.)
MSDS Chinese USA Flash Point 154.4±23.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Boc-NH-C4-acid


Boc-NH-C4-acid is a PROTAC linker, which belongs to a Alkyl/ether linker. Boc-NH-C4-acid can be used in the synthesis of the compound PROTAC1, and specifically degrades EED, EZH2, and SUZ12 in the PRC2 Complex.

 Names

Name 5-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid
Synonym More Synonyms

 Boc-NH-C4-acid Biological Activity

Description Boc-NH-C4-acid is a PROTAC linker, which belongs to a Alkyl/ether linker. Boc-NH-C4-acid can be used in the synthesis of the compound PROTAC1, and specifically degrades EED, EZH2, and SUZ12 in the PRC2 Complex.
Related Catalog
Target

Alkyl/ether

References

[1]. [1].Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 331.7±27.0 °C at 760 mmHg
Melting Point 48-52 °C(lit.)
Molecular Formula C10H19NO4
Molecular Weight 217.262
Flash Point 154.4±23.7 °C
Exact Mass 217.131409
PSA 75.63000
LogP 0.84
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.475
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2924199090

 Synthetic Route

~95%

Boc-NH-C4-acid Structure

Boc-NH-C4-acid

CAS#:27219-07-4

Literature: Gavande, Navnath; Kim, Hye-Lim; Doddareddy, Munikumar R.; Johnston, Graham A. R.; Chebib, Mary; Hanrahan, Jane R. ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 4 p. 402 - 407

~47%

Boc-NH-C4-acid Structure

Boc-NH-C4-acid

CAS#:27219-07-4

Literature: Lippard, Stephen J.; Barnes, Carmen M.; Haskel, Ariel; Barnes, Katie R. Patent: US2004/235712 A1, 2004 ; Location in patent: Page/Page column 34 ;

~90%

Boc-NH-C4-acid Structure

Boc-NH-C4-acid

CAS#:27219-07-4

Literature: Flynn, Daniel L.; Zelle, Robert E.; Grieco, Paul A. Journal of Organic Chemistry, 1983 , vol. 48, # 14 p. 2424 - 2426

~75%

Boc-NH-C4-acid Structure

Boc-NH-C4-acid

CAS#:27219-07-4

Literature: Hartlieb, Matthias; Pretzel, David; Kempe, Kristian; Fritzsche, Carolin; Paulus, Renzo M.; Gottschaldt, Michael; Schubert, Ulrich S. Soft Matter, 2013 , vol. 9, # 18 p. 4693 - 4704

~94%

Boc-NH-C4-acid Structure

Boc-NH-C4-acid

CAS#:27219-07-4

Literature: Ishida, Hideharu; Ogawa, Yuji; Imai, Yasuyuki; Kiso, Makoto; Hasegawa, Akira; et al. Carbohydrate Research, 1989 , vol. 194, p. 199 - 208

~%

Boc-NH-C4-acid Structure

Boc-NH-C4-acid

CAS#:27219-07-4

Literature: Nisshin Flour Milling Co., Ltd. Patent: US6252041 B1, 2001 ;

~%

Boc-NH-C4-acid Structure

Boc-NH-C4-acid

CAS#:27219-07-4

Literature: Flynn, Daniel L.; Zelle, Robert E.; Grieco, Paul A. Journal of Organic Chemistry, 1983 , vol. 48, # 14 p. 2424 - 2426

~%

Boc-NH-C4-acid Structure

Boc-NH-C4-acid

CAS#:27219-07-4

Literature: Flynn, Daniel L.; Zelle, Robert E.; Grieco, Paul A. Journal of Organic Chemistry, 1983 , vol. 48, # 14 p. 2424 - 2426

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

5-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)pentanoic acid
5-[(tert-Butoxycarbonyl)amino]pentanoic acid
5-(N-t-butoxycarbonylamino)pentanoic acid
5-[[(1,1-Dimethylethoxy)carbonyl]amino]-pentanoic acid
MFCD00076903
5-[(tert-Butoxycarbonyl)amino]valeric Acid
5-(Boc-amino)valeric acid
Boc-5-Ava-OH
N-(tert-Butoxycarbonyl)-5-aminovaleric Acid
2-Methyl-2-propanyl 6-hydroxy-6-oxonorleucinate
Hexanedioic acid, 2-amino-, 1-(1,1-dimethylethyl) ester
5-(Boc-amino)pentanoic Acid
5-(tert-Butoxycarbonylamino)pentanoic Acid
5-(N-Boc-amino)valeric acid
N-Boc-5-aminovaleric Acid
5-Boc-amino-pentanoic acid
5-(tert-Butoxycarbonylamino)valeric Acid
N-Boc-5-aminopentanoic Acid
5-(N-t-butoxycarbonylamino)valeric acid
Pentanoic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-
boc-5-aminovaleric acid
5-(N-tert-butoxycarbonylamino)-pentanoic acid
5-(N-t-butyloxycarbonylamino)-pentanoic acid
N-(tert-Butoxycarbonyl)-5-aminopentanoic Acid
Boc-5-aminopentanoic acid
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