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1137109-21-7

1137109-21-7 structure
1137109-21-7 structure
  • Name: Mal-amido-PEG6-NHS ester
  • Chemical Name: Mal-PEG6-NHS
  • CAS Number: 1137109-21-7
  • Molecular Formula: C26H39N3O13
  • Molecular Weight: 601.60000
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-03-14 08:00:00
  • Modify Date: 2025-08-23 16:56:58
  • Mal-amido-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Mal-PEG6-NHS
Synonyms α-Maleimidopropionyl-ω-succinimidyl-6(ethylene glycol)
Description Mal-amido-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Molecular Formula C26H39N3O13
Molecular Weight 601.60000
Exact Mass 601.24800
PSA 185.54000
Storage condition -20°C
Hazard Codes Xi
RIDADR NONH for all modes of transport
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