Mal-amido-PEG6-NHS ester

Modify Date: 2024-01-05 18:00:56

Mal-amido-PEG6-NHS ester Structure
Mal-amido-PEG6-NHS ester structure
Common Name Mal-amido-PEG6-NHS ester
CAS Number 1137109-21-7 Molecular Weight 601.60000
Density N/A Boiling Point N/A
Molecular Formula C26H39N3O13 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mal-amido-PEG6-NHS ester


Mal-amido-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Mal-PEG6-NHS
Synonym More Synonyms

 Mal-amido-PEG6-NHS ester Biological Activity

Description Mal-amido-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C26H39N3O13
Molecular Weight 601.60000
Exact Mass 601.24800
PSA 185.54000
Storage condition -20°C

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport

 Synonyms

α-Maleimidopropionyl-ω-succinimidyl-6(ethylene glycol)
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