1244040-64-9

1244040-64-9 structure
1244040-64-9 structure
  • Name: Tetrazine-Ph-NHCO-C3-NHS ester
  • Chemical Name: 2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate
  • CAS Number: 1244040-64-9
  • Molecular Formula: C18H18N6O5
  • Molecular Weight: 398.37300
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-04-06 11:05:54
  • Modify Date: 2024-01-23 10:01:47
  • Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate
Description Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Molecular Formula C18H18N6O5
Molecular Weight 398.37300
Exact Mass 398.13400
PSA 144.34000
LogP 0.65610
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
RIDADR NONH for all modes of transport