Henan Tianfu Chemical Co., Ltd.
China
Product Name: eplerenone
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

107724-20-9

107724-20-9 structure

Name: Eplerenone
Chemical Name: eplerenone
CAS Number: 107724-20-9
Molecular Formula: C₂₄H₃₀O₆
Molecular Weight: 414.491
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-05-17 08:00:00
Modify Date: 2026-07-12 18:24:41
Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM.Target: Mineralocorticoid ReceptorEplerenone is a selective mineralocorticoid receptor antagonist, which has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors [1]. Benefits of eplerenone therapy over placebo were also observed in several secondary outcomes, including: death from any cause or hospitalization for HF; death from any cause; hospitalization for any reason; or hospitalization for HF [2].

Name	eplerenone
Synonyms	lerenone CRS lerenone selective mineralocorticoid antagonist plerenone pregn-4-ene-7,21-dicboxylic acid, 9,11-oxy-17-hydroxy-3-oxo, γ-lactone, methyl ester (7 α, 11 α, 17 α) LERENONE STANDD 9,11a-Epoxy-17-hydroxy-3-oxo-17a-pregn-4-ene-7a,21-dicarboxylic Acid g-Lactone Methyl Ester SC-66110 9,11alpha-oxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicboxylic Acid gamma-Lactone Methyl Ester lerenone for peak identification CRS Methyl (4aS,4bR,5aR,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate (+)-lerenone lerenone, Selective mineralocorticoid antagonist PREGNA-4-ENE-7,21-DICBOXYLIC ACID,11,17-DIHYDROXY-3-OXO,G-LACTONE,METHYLESTER,(7Α,11Α,17Α) Methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-diméthyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tétradécahydro-3H,3'H-spiro[cyclopenta[7,8]phénanthro[4b,5-b]oxirène-7,2'-furane]-10-carboxylate de méthyle Methyl-(4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxiren-7,2'-furan]-10-carboxylat lerenoneC24H3006 rolidone lerenone Hormone Raw Powder lerenone for system suitability Elperenone lerenone Q: What is lerenone Q: What is the CAS Number of lerenone Q: What is the storage condition of lerenone Q: What e the applications of lerenone (2'R,4aS,4bR,5,6aS,9aS,9bR,10R)-Methyl 4a,6a-diMethyl-2,4'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-cboxylate lerenone for system suitability CRS lerenone [USAN] (7A,11A,17A)-9,11-OXY-17-HYDROXY-3-OXO-PREGN-4-ENE-7,21-DICBOXYLIC ACID G-LACTONE METHYL ESTER epoxymexrenone spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7(3H),2'(3'H)-furan]-10-carboxylic acid, 2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-4a,6a-dimethyl-2,5'-dioxo-, methyl ester, (4aS,4bR,5aR,6aS,7 oxymexrenone Methyl (1'R,2R,2'S,9'R,10'S,11'S,15'S,17'R)-2',15'-diMethyl-5,5'-dioxo-18'-oxaspiro[oxolane-2,14'-pentacyclo[8.8.0.0^{1,17}.0^{2,7}.0^{11,15}]octadecan]-6'-ene-9'-cboxylate INSPRA;OXYMEXRENONE CGP 30083, oxymexrenone, Inspra, Spiro[9,11-oxy-9H-cyclopenta[a]phenanthrene-17(2H),2(3-furan],pregn-4-ene-7,21-dicboxylic Acid, Inspra Pregn-4-ene-7,21-dicboxylic acid, 9,11-oxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha) lerenone 9,11α-Epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic Acid γ-Lactone Methyl Ester (2'R,4aS,4bR,5,6aS,9aS,9bR,10R)-methyl 4a,6a-dimethyl-2,5'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-cboxylate lerenone, 10 mM in DMSO lenone pregn-4-ene-7,21-dicboxylic acid 9,11-oxy-17-hydroxy-3-oxo gamma-lactone methyl ester lerenone oxymexrenone Inspra EplerenoneC24H3006 Epleremone lerenone> lerenone D3Q: What is lerenone D3 Q: What is the CAS Number of lerenone D3 Q: What is the storage condition of lerenone D3 Q: What e the applications of lerenone D3 LERINONE (7α,11α,17α)-9,11-oxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicboxylicacidγ-lactonemethylester lerenone for peak identification lerenone-13C-d3 γ-Lactone 7-Methyl Ester (7a,11a,17a)-9,11-oxy-17-hydroxy-3-oxopregn-4-ene-7,21-dicboxylic Acid -Lactone 7-Methyl Ester Methyl (4aS,4bR,5,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,4'-dioxo-2,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-cboxylate LERENONE AND N-1 INTERMEDIATE lerenone RS lerenone intermediate lerenone Methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate lerenone //BP lerenone - Bio-X (7α,11α,17α)-9,11-oxy-17-hydroxy-3-oxopregn-4-ene-7,21-dicboxylic Acid Pregn-4-ene-7,21-dicboxylic acid, 9,11-oxy-17-hydroxy-3-oxo-, γ-lactone, 7-methyl ester, (7α,11α,17α) (7α,11α,17α)-9,11-oxy-17-hydroxy-3-oxo-γ-lactone-pregn-4-ene-7,21-dicboxylic acid-7-methyl ester EPLERINONE

Description	Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM.Target: Mineralocorticoid ReceptorEplerenone is a selective mineralocorticoid receptor antagonist, which has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors [1]. Benefits of eplerenone therapy over placebo were also observed in several secondary outcomes, including: death from any cause or hospitalization for HF; death from any cause; hospitalization for any reason; or hospitalization for HF [2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor Research Areas >> Cardiovascular Disease
References	[1]. Chatterjee, S., et al., Eplerenone is not superior to older and less expensive aldosterone antagonists. Am J Med, 2012. 125(8): p. 817-25. [2]. Dhillon, S., Eplerenone: a review of its use in patients with chronic systolic heart failure and mild symptoms. Drugs, 2013. 73(13): p. 1451-62.

Density	1.3±0.1 g/cm3
Boiling Point	597.9±50.0 °C at 760 mmHg
Melting Point	241-243ºC
Molecular Formula	C₂₄H₃₀O₆
Molecular Weight	414.491
Flash Point	259.5±30.2 °C
Exact Mass	414.204254
PSA	82.20000
LogP	1.05
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.587

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	3077
HS Code	29322090

Precursor 6
95716-70-4 67-56-1 192704-54-4 124-41-4
192569-17-8 95716-71-5
DownStream 0

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