Name | tolterodine |
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Synonyms |
MFCD07771985
(+)-Tolterodine 2-[(1R)-3-(Diisopropylamino)-1-phenylpropyl]-4-methylphenol (R)-2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol (R)-Tolterodine tolterodine Detrol Tolterodine L-tartrate Detrusitol Phenol, 2-((1R)-3-(bis(1-methylethyl)amino)-1-phenylpropyl)-4-methyl- TOLTERODINE TARTRATE (+)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine (+)-(R)-2-[a-[2-(Diisopropylamino)ethyl]benzyl]-p-cresol Phenol, 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl- |
Description | Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. IC50 Value:Target: mAChRin vitro: Carbachol-induced contractions of isolated guinea pig bladder were effectively inhibited by tolterodine (IC50 14 nM) and 5-HM (IC50 5.7 nM). The IC50 values were in the microM range and the antimuscarinic potency of tolterodine was 27, 200 and 370-485 times higher, respectively, than its potency in blocking histamine receptors, alpha-adrenoceptors and calcium channels. The active metabolite, 5-HM, was >900 times less potent at these sites than at bladder muscarinic receptors [1].in vivo: Tolterodine was extensively metabolized in vivo [2]. In the passive-avoidance test, tolterodine at 1 or 3 mg/kg had no effect on memory; the latency to cross and percentage of animals crossing were comparable to controls. In contrast, scopolamine induced a memory deficit; the latency to cross was decreased, and the number of animals crossing was increased [3]. |
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Related Catalog | |
References |
Density | 1.0±0.1 g/cm3 |
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Boiling Point | 442.2±45.0 °C at 760 mmHg |
Molecular Formula | C22H31NO |
Molecular Weight | 325.488 |
Flash Point | 192.1±27.4 °C |
Exact Mass | 325.240570 |
PSA | 23.47000 |
LogP | 5.77 |
Vapour Pressure | 0.0±1.1 mmHg at 25°C |
Index of Refraction | 1.548 |
Storage condition | -20°C Freezer |
Hazard Codes | Xn,Xi |
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Risk Phrases | R22:Harmful if swallowed. |
Safety Phrases | S36/37/39 |
RIDADR | 1987 |
WGK Germany | 2 |
Precursor 7 | |
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DownStream 2 | |