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Product Name: Histamine phosphate
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51-74-1

51-74-1 structure

Name: Histamine phosphate
Chemical Name: histamine phosphate
CAS Number: 51-74-1
Molecular Formula: C₅H₁₅N₃O₈P₂
Molecular Weight: 307.14
Catalog: Biochemical Inhibitor Neuronal Signaling Histamine Receptor Agonist
Create Date: 2018-02-18 08:00:00
Modify Date: 2026-07-15 17:52:56
Histamine diphosphate is a potent agonist of histamine receptors and vasodilator. It can activate nitric oxide synthetase.

Name	histamine phosphate
Synonyms	Histapon HistaMine Diphosphate Histamine acid phosphate 2-(1H-Imidazol-4-yl)ethanamine bis(phosphate) 1H-Imidazole-5-ethanamine, phosphate (1:1) Histamine diphosphate monohydrate Histamine diphosphate salt monohydrat 2-(1H-Imidazol-4-yl)ethan-1-amine bis(phosphate) HISTAMINE DIPHOSPHATE SALT HistaMine iphosphate HistamineDisphosphate 2-(1H-Imidazol-5-yl)ethanamine phosphate (1:1) 2-(1H-iMidazol-4-yl)ethanaMine diphosphate hydrate Histamine diphosphate hydrate Histamine H1/H2 rector agonist HISTAMINE DIHYDROGEN PHOSPHATE 2-(4-Imidazolyl)ethylamine diphosphate salt monohydrate 2-(4-Imidazolyl)ethylamine diphosphate salt Histamine diphosphate salt monohydrate histamine acid phosphate Histamine bisphosphate Histamine phosphate //BP MFCD00064316 2-(4-Imidazolyl)ethylamine diphosphate salt, 2-(4-Imidazolyl)ethylamine monohydrate diphosphate salt, Histamine monohydrate diphosphate salt 4-(2-aminoethyl)imidazolebis(dihydrogenphosphate) EINECS 200-118-4 Histamine Hydrate HistaMine bisphosphate Monohydrate >= (NT) 2-(1H-IMidazol-4-yl)ethanaMine bis(phosphate) histamine,phosphate(1:2) 2-(4-Imidazolyl)ethylamine diphosphate salt monohydrate Histamine diphosphate hydrate a histamine H1/H2 rector agonist histaminedihydrogenphosphate HistamineDiphosphate HISTAMINE PHOSPHATE 1 Histamine phosphate Histamine diphosphat 2-(4-imidazolyl)ethylamine diphosphate diphosphate salt monohydrate histaminebiphosphate Histamine bisphosphate monohydrate,2-(4-Imidazolyl)ethylamine diphosphate salt monohydrate, 2-(4-Imidazolyl)ethylamine diphosphate salt, Histamine diphosphate salt monohydrate 2-imidazol-4-ylethylamine-orthophosphoricacid Histamine phosphate (Histamine diphosphate) HistamineDiphosphateHydrate> Histamine Diphosphate Hydrate HISTAMINHOSPHATE 1h-imidazole-4-ethanamine,phosphate(1:2) 2-imidazol-4-ylethylamine-orthophosphoric acid (1:2) 4-(2-aminoethyl)imidazoledi-acidphosphate

Description	Histamine diphosphate is a potent agonist of histamine receptors and vasodilator. It can activate nitric oxide synthetase.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease
References	[1]. Rietveld S et al. The influence of respiratory sounds on breathlessness in children with asthma: a symptom-perceptionapproach. [2]. Rietveld S et al. The influence of respiratory sounds on breathlessness in children with asthma: a symptom-perceptionapproach. Health Psychol. 1997 Nov;16(6):547-53.

Boiling Point	887.3ºC at 760 mmHg
Melting Point	128-132 °C
Molecular Formula	C₅H₁₅N₃O₈P₂
Molecular Weight	307.14
Flash Point	490.4ºC
PSA	142.27000
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI5425000

CAS REGISTRY NUMBER :: 51-74-1

LAST UPDATED :: 199712

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C5-H9-N3.2H3-O4-P

MOLECULAR WEIGHT :: 307.17

WISWESSER LINE NOTATION :: T5M CNJ D2Z &P-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1781 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 119,444,1957

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 24,101,1925

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 807 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 122,685,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 913 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 59,1659,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 333 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 90,726,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2763 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 75,299,1942

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 24,101,1925

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 608 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - bronchiolar constriction

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 57,1543,1968

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 746 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1574,1970 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 62500 ug/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 32,45B,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1137 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 132 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1137 No. of Facilities: 27 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1688 (estimated) No. of Female Employees: 1252 (estimated)

Symbol	GHS05, GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H315-H317-H318-H334-H335
Precautionary Statements	P261-P280-P305 + P351 + P338-P342 + P311
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn
Risk Phrases	20/21/22-36/37/38-42/43-41-37/38-22
Safety Phrases	S26-S36-S45-S36/37/39-S22
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	NI5425000
HS Code	2933290090

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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