98192-64-4

98192-64-4 structure

Name: isodispar B
Chemical Name: isodispar B
CAS Number: 98192-64-4
Molecular Formula: C₂₀H₁₈O₅
Molecular Weight: 338.35400
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-05-17 04:36:41
Modify Date: 2024-01-09 12:19:13
Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines[1].

Name	isodispar B
Synonyms	5,7-dihydroxy-8-(2-methyl-1-oxobutyl)-4-phenyl-2H-[1]benzopyran-2-one 5,7-dihydroxy-8-(3-methylbutyryl)-4-phenylcoumarin 8-(3-methylbutyryl)-4-phenyl-5,7-dihydroxycoumarin 5,7-dihydroxy-8-(3-methyl-butyryl)-4-phenyl-chromen-2-one

Description	Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Isodispar B (化合物 1) (0-100 μM; 72 h) 具有广谱的抗癌活性，抑制细胞增殖，IC50 为 3.84-56.73 μM[1]。 Isodispar B (1 μM 和 10 μM; 3 d) 诱导鼻咽癌细胞 (TW01、CNE1、HK1、SUNE1) 凋亡[1]。 Cell Cytotoxicity Assay[1] Cell Line: Nasopharyngeal cancer cells (TW01, CNE1, HK1, and SUNE1) and noncancerous nasopharyngeal cells (NP460) Concentration: 0-100 μM Incubation Time: 72 hours Result: Showed cytotoxicity and inhibited cell viability with IC50s of 3.84 μM (SUNE1), 11.49 μM (TW01), 9.74 μM (CNE1), 5.58 μM (HK1), 56.73 μM (HCC38), 52.69 μM (MDA-MB-231), 52.75 μM (MDA-ME-468), and 54.85 μM (SKBR3), respectively.
References	[1]. Lim C K, et al. In vitro cytotoxic activity of isolated compounds from Malaysian Calophyllum species[J]. Medicinal Chemistry Research, 2016, 25(8): 1686-1694.