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32775-08-9

32775-08-9 structure
32775-08-9 structure
  • Name: CH2COOH-PEG3-CH2COOH
  • Chemical Name: 3,6,9,12-tetraoxatetradecane-1,14-dioic acid
  • CAS Number: 32775-08-9
  • Molecular Formula: C10H18O8
  • Molecular Weight: 266.24500
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-04-30 10:38:33
  • Modify Date: 2024-01-09 17:44:18
  • CH2COOH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 3,6,9,12-tetraoxatetradecane-1,14-dioic acid
Synonyms 3,6,9,12-tetraoxatetradecanedioic acid
3,6,9,12-tetraoxa-1,14-tetradecandioic acid
triethyleneglycol diacetic acid
triethyleneglycol diglycolide
TEG-diGL
Description CH2COOH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula C10H18O8
Molecular Weight 266.24500
Exact Mass 266.10000
PSA 111.52000
Hazard Codes C