CH2COOH-PEG3-CH2COOH

Modify Date: 2024-01-09 17:44:18

CH2COOH-PEG3-CH2COOH Structure
CH2COOH-PEG3-CH2COOH structure
Common Name CH2COOH-PEG3-CH2COOH
CAS Number 32775-08-9 Molecular Weight 266.24500
Density N/A Boiling Point N/A
Molecular Formula C10H18O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CH2COOH-PEG3-CH2COOH


CH2COOH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3,6,9,12-tetraoxatetradecane-1,14-dioic acid
Synonym More Synonyms

 CH2COOH-PEG3-CH2COOH Biological Activity

Description CH2COOH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C10H18O8
Molecular Weight 266.24500
Exact Mass 266.10000
PSA 111.52000

 Safety Information

Hazard Codes C

 Synonyms

3,6,9,12-tetraoxatetradecanedioic acid
3,6,9,12-tetraoxa-1,14-tetradecandioic acid
triethyleneglycol diacetic acid
triethyleneglycol diglycolide
TEG-diGL