108005-94-3

108005-94-3 structure

Name: Z-Phe-Phe-FMK
Chemical Name: 3-benzyloxycarbonylphenylalanylamino-1-fluoro-4-phenyl-2-butanone
CAS Number: 108005-94-3
Molecular Formula: C₂₇H₂₇FN₂O₄
Molecular Weight: 462.51
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cathepsin
Create Date: 2018-03-01 21:26:36
Modify Date: 2025-09-18 02:16:35
Cathepsin L-IN-2 (Z-Phe-Phe-FMK) is a potent and irreversible cathepsin L and cathepsin B inhibitor[1][2].

Name	3-benzyloxycarbonylphenylalanylamino-1-fluoro-4-phenyl-2-butanone
Synonyms	zff-fmk z-ff-fmk cathepsin l inhibitor i Cathepsin L-IN-2

Description	Cathepsin L-IN-2 (Z-Phe-Phe-FMK) is a potent and irreversible cathepsin L and cathepsin B inhibitor[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
References	[1]. Jonathan Frew, et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener. 2020 Mar 16;15(1):21. [2]. Kirsi Ravanko, et al. Cysteine cathepsins are central contributors of invasion by cultured adenosylmethionine decarboxylase-transformed rodent fibroblasts. Cancer Res. 2004 Dec 15;64(24):8831-8.