80407-56-3

80407-56-3 structure

Name: Lysine-methotrexate
Chemical Name: Nα-(4-amino-4-deoxy-N10-methylpteroyl)-L-lysine
CAS Number: 80407-56-3
Molecular Formula: C₂₁H₂₇N₉O₃
Molecular Weight: 453.49800
Catalog: Signaling Pathways Cell Cycle/DNA Damage Antifolate
Create Date: 2018-06-13 10:58:44
Modify Date: 2024-01-11 18:48:45
Lysine-methotrexate, an analogue of Methotrexate (HY-14519), is a dihydrofolate reductase (DHFR) inhibitor[1].

Name	Nα-(4-amino-4-deoxy-N10-methylpteroyl)-L-lysine
Synonyms	(S)-6-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-hexanoic acid

Description	Lysine-methotrexate, an analogue of Methotrexate (HY-14519), is a dihydrofolate reductase (DHFR) inhibitor[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate Research Areas >> Inflammation/Immunology
References	[1]. Kempton RJ, et al. Lysine and ornithine analogues of methotrexate as inhibitors of dihydrofolate reductase. J Med Chem. 1982 Apr;25(4):475-7.