Lysine-methotrexate

Modify Date: 2024-01-11 18:48:45

Lysine-methotrexate Structure
Lysine-methotrexate structure
Common Name Lysine-methotrexate
CAS Number 80407-56-3 Molecular Weight 453.49800
Density N/A Boiling Point N/A
Molecular Formula C21H27N9O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Lysine-methotrexate


Lysine-methotrexate, an analogue of Methotrexate (HY-14519), is a dihydrofolate reductase (DHFR) inhibitor[1].

 Names

Name Nα-(4-amino-4-deoxy-N10-methylpteroyl)-L-lysine
Synonym More Synonyms

 Lysine-methotrexate Biological Activity

Description Lysine-methotrexate, an analogue of Methotrexate (HY-14519), is a dihydrofolate reductase (DHFR) inhibitor[1].
Related Catalog
References

[1]. Kempton RJ, et al. Lysine and ornithine analogues of methotrexate as inhibitors of dihydrofolate reductase. J Med Chem. 1982 Apr;25(4):475-7.  

 Chemical & Physical Properties

Molecular Formula C21H27N9O3
Molecular Weight 453.49800
Exact Mass 453.22400
PSA 199.26000
LogP 2.78620

 Synonyms

(S)-6-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-hexanoic acid
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