101219-61-8

101219-61-8 structure

Name: Picrasidine Q
Chemical Name: 4-hydroxy-5-methoxy-canthin-6-one
CAS Number: 101219-61-8
Molecular Formula: C₁₅H₁₀N₂O₃
Molecular Weight: 266.25200
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-03-14 08:00:00
Modify Date: 2024-01-25 09:21:09
Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits FGFR2 kinase activity[1].

Name	4-hydroxy-5-methoxy-canthin-6-one
Synonyms	5-methoxy-4-hydroxycanthin-6-one picrasidine Q 4-Hydroxy-5-methoxy-indolo[3,2,1-de][1,5]naphthyridin-6-one 4-hydroxy-5-methoxycanthin-6-one

Description	Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits FGFR2 kinase activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR
Target	FGFR2
In Vitro	Picrasidine Q (0~60 μM; 3 hours; ESCC cells) suppresses downstream signaling of FGFR2 in ESCC cells[1]. Picrasidine Q (0~60 μM; 48 and 72 hours; ESCC cells) induces cell cycle arrest and apoptosis[1]. Picrasidine Q (0~60 μM; 24~72 hours; ESCC cells) suppresses the growth of ESCC cells[1]. Picrasidine Q (0~60 μM; 30 minutes; JB6Cl41 cells) inhibits proliferation by inhibition of G1/S cell cycle transition[1]. Picrasidine Q (12.5, 25 or 50 μM) can inhibit the FGFR2 kinase activity in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: ESCC cells Concentration: 0~60 μM Incubation Time: 3 hours Result: Suppressed downstream signaling of FGFR2 in ESCC cells. Apoptosis Analysis[1] Cell Line: ESCC cells Concentration: 0~60 μM Incubation Time: 48 and 72 hours Result: Induced cell cycle arrest and apoptosis. Cell Cytotoxicity Assay[1] Cell Line: ESCC cells Concentration: 0~60 μM Incubation Time: 24~72 hours Result: Suppressed the growth of ESCC cells. Cell Cycle Analysis[1] Cell Line: JB6Cl41 cells Concentration: 0~60 μM Incubation Time: 30 minutes Result: Inhibited proliferation by inhibition of G1/S cell cycle transition.
References	[1]. Shi Y, et al. FGFR2 regulation by picrasidine Q inhibits the cell growth and induces apoptosis in esophageal squamous cell carcinoma. J Cell Biochem. 2018;119(2):2231-2239.

Molecular Formula	C₁₅H₁₀N₂O₃
Molecular Weight	266.25200
Exact Mass	266.06900
PSA	63.83000
LogP	2.15290

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