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  • DC Chemicals Limited
  • China
  • Product Name: Tectol
  • Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

24449-39-6

24449-39-6 structure
24449-39-6 structure
  • Name: Tectol
  • Chemical Name: tectol
  • CAS Number: 24449-39-6
  • Molecular Formula: C30H26O4
  • Molecular Weight: 450.52500
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Farnesyl Transferase
  • Create Date: 2018-01-16 13:24:26
  • Modify Date: 2024-01-10 06:58:54
  • Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM[1]. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM[1][2].

Name tectol
Synonyms 2,2,2',2'-tetramethyl-2H,2'H-[5,5']bi[benzo[h]chromenyl]-6,6'-diol
Tectol
2,2,2',2'-Tetramethyl-2H,2'H-[5,5']bi[benzo[h]chromenyl]-6,6'-diol
Description Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM[1]. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM[1][2].
Related Catalog
References

[1]. Costa SM, et al. Chemical constituents from Lippia sidoides and cytotoxic activity. J Nat Prod. 2001;64(6):792-795.

[2]. Cadelis MM, et al. Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors. Bioorg Med Chem. 2016;24(14):3102-3107.

Molecular Formula C30H26O4
Molecular Weight 450.52500
Exact Mass 450.18300
PSA 58.92000
LogP 7.43960
Hazard Codes Xi