DC Chemicals Limited
China
Product Name: BMY 29304
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

164802-68-0

164802-68-0 structure

Name: BMY 29304
Chemical Name: siamycin I
CAS Number: 164802-68-0
Molecular Formula: C₉₇H₁₃₁N₂₃O₂₆S₄
Molecular Weight: 2163.48000
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2018-04-02 16:52:40
Modify Date: 2024-02-02 00:47:42
Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a HIV fusion inhibitor with ED50s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research[1][2][3][4].

Name	siamycin I

Description	Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a HIV fusion inhibitor with ED50s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research[1][2][3][4].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	HIV-1 HIV-2
In Vitro	Siamycin I 浓度为 1 μM 轻微抑制 E. faecalis 的生长 (接种后 5 小时生长 80%)，浓度为 5 μM 时完全抑制生长 (接种后 12 小时无生长)[3]。 siamycin I (0-1 μM; 24 小时) 在 0.25 μM 浓度下轻微抑制生物膜形成，浓度高于 0.5 μM 时抑制作用显着[3]。 Siamycin I 抑制 C8166 细胞与慢性感染 HIV 的 CEM-SS 细胞之间的融合 (ED50=0.08 μM)，但对 Sendai 病毒诱导的融合或小鼠成肌细胞融合没有影响[4]。
References	[1]. Pikyee Ma, et al. Anti-HIV siamycin I directly inhibits autophosphorylation activity of the bacterial FsrC quorum sensor and other ATP-dependent enzyme activities. FEBS Lett. 2011 Sep 2;585(17):2660-4. [2]. Stephanie Tan, et al. The Lasso Peptide Siamycin-I Targets Lipid II at the Gram-Positive Cell Surface. ACS Chem Biol. 2019 May 17;14(5):966-974. [3]. Jiro Nakayama, et al. Siamycin attenuates fsr quorum sensing mediated by a gelatinase biosynthesis-activating pheromone in Enterococcus faecalis. J Bacteriol. 2007 Feb;189(4):1358-65. [4]. M Tsunakawa, et al. Siamycins I and II, new anti-HIV peptides: I. Fermentation, isolation, biological activity and initial characterization. J Antibiot (Tokyo). 1995 May;48(5):433-4.

Molecular Formula	C₉₇H₁₃₁N₂₃O₂₆S₄
Molecular Weight	2163.48000
Exact Mass	2161.85000
PSA	848.94000
LogP	2.16980

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

164802-68-0	1189644-16-3
116143-32-9	1346604-28-1
152575-66-1	105565-55-7
21102-95-4	132195-65-4
106872-71-3	78441-82-4
2034358-60-4	2034358-67-1
2034540-23-1	2034575-73-8
2034358-74-0	2034575-80-7
2034515-17-6	2034575-98-7
2034576-64-0	2034468-09-0