149859-17-6

149859-17-6 structure

Name: MDL 101146
Chemical Name: mdl 101,146
CAS Number: 149859-17-6
Molecular Formula: C₂₉H₃₇F₅N₄O₆
Molecular Weight: 632.61900
Catalog: Signaling Pathways Metabolic Enzyme/Protease Elastase
Create Date: 2018-03-18 17:07:32
Modify Date: 2024-01-05 15:51:40
MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis[1][2].

Name	mdl 101,146
Synonyms	N-[4-(4-morpholinylcarbonyl)benzoyl]-L-valyl-N-[3,3,4,4,4-pentafluoro-1-(1-methylethyl)-2-oxobutyl]-L-prolinamide (S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-benzoylamino]-butyryl}-pyrrolidine-2-carboxylic acid (3,3,4,4,4-pentafluoro-1-isopropyl-2-oxo-butyl)-amide [4-(4-morpholinylcarbonyl)benzoyl]Val-Pro-L,D-Val pentafluoroethylketone

Description	MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase Research Areas >> Inflammation/Immunology
Target	Ki for neutrophil elastase: 25 nM (human); 18 nM (rat)[1][2]
In Vitro	MDL 101,146 inhibits human neutrophil elastase with a Ki value of 25 nM[1]. MDL 101,146 inhibits rat neutrophil elastase activity in a dose-related manner with a Ki value of 18 nM[2].
In Vivo	MDL 101146 (oral, 200 mg/kg/day) significantly inhibits swelling and joint destruction in collagen-induced arthritis but not in adjuvant arthritis[2]. Animal Model: Rats[2] Dosage: 200 mg/kg Administration: Oral, 200 mg/kg/day Result: Inhibited the severity of collagen-induced arthritis. Had a bone and cartilage sparing effect in the tibio-tarsal joint of animals with collagen-induced arthritis.