24063-71-6

24063-71-6 structure

Name: Isocurcumenol
Chemical Name: 3S-(3α,3aα,6α,8aβ)-octahydro-3-methyl-8-methylene-5-(1-methylethylidene)-6H-3a,6-epoxyazulen-6-ol
CAS Number: 24063-71-6
Molecular Formula: C₁₅H₂₂O₂
Molecular Weight: 234.334
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-08-01 22:10:12
Modify Date: 2024-01-08 10:31:52
Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC50 values of 99.1µg/mL and 178.2 µg/mL in DLA and KB cells, respectively[1][2].

Name	3S-(3α,3aα,6α,8aβ)-octahydro-3-methyl-8-methylene-5-(1-methylethylidene)-6H-3a,6-epoxyazulen-6-ol
Synonyms	Isocurcumenol 9-Isopropylidene-2-methyl-6-methylene-11-oxatricyclo[6.2.1.0]undecan-8-ol isocurcomenol 6H-3a,6-Epoxyazulen-6-ol, octahydro-3-methyl-8-methylene-5-(1-methylethylidene)- (1S,2S,5S,8R)-9-Isopropylidene-2-methyl-6-methylene-11-oxa-tricyclo[6.2.1.01,5]undecan-8-ol (3a,3aα,6α,8aβ)-5-isopropylidene-3-methyl-8-methylene-3a,6-epoxyperhydroazulen-6-ol Isourecumenol

Description	Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC50 values of 99.1µg/mL and 178.2 µg/mL in DLA and KB cells, respectively[1][2].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Signaling Pathways >> Apoptosis >> Apoptosis
In Vitro	Isocurcumenol (12.5-400 µg/mL, 24-48 h) dose-dependently inhibits cancer cells proliferation[1]. isocurcumenol does not exhibit any significant toxicity on normal chicken embryo fibroblast cells and lymphocytes[1].
References	[1]. Lakshmi S, et al. Antitumour Effects of Isocurcumenol Isolated from Curcuma zedoaria Rhizomes on Human and Murine Cancer Cells. Int J Med Chem. 2011;2011:253962. [2]. Resmi Mustarichiei, et al. In silico study of curcumol, curcumenol, isocurcumenol, and β-sitosterol as potential inhibitors of estrogen receptor alpha of breast cancer. Basic Medical Research. 2014