Isocurcumenol

Modify Date: 2024-01-08 10:31:52

Isocurcumenol Structure
Isocurcumenol structure
Common Name Isocurcumenol
CAS Number 24063-71-6 Molecular Weight 234.334
Density 1.1±0.1 g/cm3 Boiling Point 351.0±42.0 °C at 760 mmHg
Molecular Formula C15H22O2 Melting Point 142-143℃
MSDS N/A Flash Point 147.9±22.1 °C

 Use of Isocurcumenol


Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC50 values of 99.1µg/mL and 178.2 µg/mL in DLA and KB cells, respectively[1][2].

 Names

Name 3S-(3α,3aα,6α,8aβ)-octahydro-3-methyl-8-methylene-5-(1-methylethylidene)-6H-3a,6-epoxyazulen-6-ol
Synonym More Synonyms

 Isocurcumenol Biological Activity

Description Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC50 values of 99.1µg/mL and 178.2 µg/mL in DLA and KB cells, respectively[1][2].
Related Catalog
In Vitro Isocurcumenol (12.5-400 µg/mL, 24-48 h) dose-dependently inhibits cancer cells proliferation[1]. isocurcumenol does not exhibit any significant toxicity on normal chicken embryo fibroblast cells and lymphocytes[1].
References

[1]. Lakshmi S, et al. Antitumour Effects of Isocurcumenol Isolated from Curcuma zedoaria Rhizomes on Human and Murine Cancer Cells. Int J Med Chem. 2011;2011:253962.

[2]. Resmi Mustarichiei, et al. In silico study of curcumol, curcumenol, isocurcumenol, and β-sitosterol as potential inhibitors of estrogen receptor alpha of breast cancer. Basic Medical Research. 2014

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 351.0±42.0 °C at 760 mmHg
Melting Point 142-143℃
Molecular Formula C15H22O2
Molecular Weight 234.334
Flash Point 147.9±22.1 °C
Exact Mass 234.161987
PSA 29.46000
LogP 3.46
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.546

 Synonyms

Isocurcumenol
9-Isopropylidene-2-methyl-6-methylene-11-oxatricyclo[6.2.1.0]undecan-8-ol
isocurcomenol
6H-3a,6-Epoxyazulen-6-ol, octahydro-3-methyl-8-methylene-5-(1-methylethylidene)-
(1S,2S,5S,8R)-9-Isopropylidene-2-methyl-6-methylene-11-oxa-tricyclo[6.2.1.01,5]undecan-8-ol
(3a,3aα,6α,8aβ)-5-isopropylidene-3-methyl-8-methylene-3a,6-epoxyperhydroazulen-6-ol
Isourecumenol