121839-78-9

121839-78-9 structure

Name: (-)-Ibuprofenamide
Chemical Name: (2R)-2-[4-(2-methylpropyl)phenyl]propanamide
CAS Number: 121839-78-9
Molecular Formula: C₁₃H₁₉NO
Molecular Weight: 205.30
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-06-23 08:36:06
Modify Date: 2024-01-09 16:38:25
(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity[1]. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[2].

Name	(2R)-2-[4-(2-methylpropyl)phenyl]propanamide
Synonyms	(R)-2-(4-Isobutyl-phenyl)-propionamide (R)-2-(4-isobutylphenyl)propionamide

Description	(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity[1]. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	COX-1, COX-2[2]
References	[1]. Shanbhag VR, et al. Ester and amide prodrugs of ibuprofen and naproxen: synthesis, anti-inflammatory activity, and gastrointestinal toxicity. J Pharm Sci. 1992 Feb;81(2):149-54. [2]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7.