40632-23-3

40632-23-3 structure

Name: 2'-Deoxyuridine-d2-1
Chemical Name: 2'-deoxyuridine-5,6-d2
CAS Number: 40632-23-3
Molecular Formula: C₉H₁₀D₂N₂O₅
Molecular Weight: 230.214
Catalog: Research Areas Infection
Create Date: 2018-02-12 08:00:00
Modify Date: 2024-01-11 15:52:36
2'-Deoxyuridine-d2-1 is the deuterium labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].

Name	2'-deoxyuridine-5,6-d2
Synonyms	2,4(1H,3H)-Pyrimidinedione-5,6-d, 1-(2-deoxy-β-L-erythro-pentofuranosyl)- 1-(2-Deoxy-β-L-erythro-pentofuranosyl)-2,4(1H,3H)-(5,6-H)pyrimidinedione

Description	2'-Deoxyuridine-d2-1 is the deuterium labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].
Related Catalog	Research Areas >> Infection
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Reidy JA, et al. Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes. Am J Med Genet. 1987 Jan;26(1):1-5.