109844-92-0
109844-92-0 structure
- Name: 5-nitro-furan-2-carboxylic acid-(4-chloro-anilide)
- Chemical Name: 5-nitro-furan-2-carboxylic acid-(4-chloro-anilide)
- CAS Number: 109844-92-0
- Molecular Formula: C11H7ClN2O4
- Molecular Weight: 266.63700
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-05-29 02:02:30
- Modify Date: 2024-01-11 14:54:06
-
LCS3 inhibits glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) (IC50=3.3 µM and 3.8 µM, respectively) synergistically. LCS3 shows anti-tumor activity, and induces apoptosis. LCS3 can be used in lung adenocarcinoma (LUAD) research[1].
| Name | 5-nitro-furan-2-carboxylic acid-(4-chloro-anilide) |
|---|---|
| Synonyms |
5-nitro-furan-2-carboxylic acid (4-chloro-phenyl)-amide
SKI-98698 5-Nitro-furan-2-carbonsaeure-(4-chlor-anilid) 5-Nitro-furan-2-carboxylic acid (4-chloro-phenyl)-amide |
| Description | LCS3 inhibits glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) (IC50=3.3 µM and 3.8 µM, respectively) synergistically. LCS3 shows anti-tumor activity, and induces apoptosis. LCS3 can be used in lung adenocarcinoma (LUAD) research[1]. |
|---|---|
| Related Catalog | |
| In Vitro | LCS3 (5 nM-10 µM; 96 h) inhibits lung cancer cell lines, but not non-transformed lung cells[1]. LCS3 (3 µM; 96 h) selectively kills lung adenocarcinoma (LUAD) cell lines, in part through the induction of apoptosis[1]. LCS3 induces ROS and NRF2 pathway activation in sensitive lung adenocarcinoma (LUAD) cells[1]. Cell Viability Assay[1] Cell Line: Non-small cell lung cancer (NSCLC) cells and non-transformed lung cells Concentration: 5 nM-10 µM Incubation Time: 96 hours Result: Inhibited the growth of 24/25 NSCLC cell lines at low micromolar concentrations (IC50<5 µM), both of the non-transformed lung cell lines were relatively insensitive (IC50>10 µM). Apoptosis Analysis[1] Cell Line: lung adenocarcinoma (LUAD) cells Concentration: 3 µM Incubation Time: 96 hours Result: Increased cleavage of caspase 3, caspase 7 and/or PARP1 in all LCS3-sensitive LUAD cell lines. Cell Viability Assay[1] Cell Line: H23 and H1650 cells Concentration: 3 µM Incubation Time: 3, 6, and 12 hours Result: Responded to LCS3 by accumulating ROS and activating the NRF2 transcription program. |
| References |
| Molecular Formula | C11H7ClN2O4 |
|---|---|
| Molecular Weight | 266.63700 |
| Exact Mass | 266.00900 |
| PSA | 88.06000 |
| LogP | 3.68970 |