Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Clausine E
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182261-83-2

182261-83-2 structure

182261-83-2 structure

Name: clausine E
Chemical Name: clausine E
CAS Number: 182261-83-2
Molecular Formula: C₁₄H₁₁NO₃
Molecular Weight: 241.24
Create Date: 2018-04-09 20:33:37
Modify Date: 2025-08-26 00:36:44
Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells.

Name	clausine E
Synonyms	methyl 1-hydroxy-9H-carbazole-3-carboxylate 1-Hydroxy-9H-carbazole-3-carboxylic acid methyl ester clauszoline I clauszoline-I clausine-E

Description	Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Wang Y, Li J, Han X, et al. Identification of Clausine E as an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. J Mol Recognit. 2019;32(10):e2800. [2]. Guo JM, Yu XM, Jiang B, et al. Zhongguo Zhong Yao Za Zhi. 2021;46(17):4438-4445. [3]. Liger F, Popowycz F, Besson T, Picot L, Galmarini CM, Joseph B. Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres. Bioorg Med Chem. 2007;15(16):5615-5619.

Molecular Formula	C₁₄H₁₁NO₃
Molecular Weight	241.24
Exact Mass	241.07400
PSA	62.32000
LogP	2.81330

Hazard Codes	Xi

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