clausine E

Modify Date: 2024-01-17 16:38:59

clausine E structure	Common Name	clausine E
	CAS Number	182261-83-2	Molecular Weight	241.24
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₁NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of clausine E

Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells.

Name	clausine E
Synonym	More Synonyms

Description	Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Wang Y, Li J, Han X, et al. Identification of Clausine E as an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. J Mol Recognit. 2019;32(10):e2800. [2]. Guo JM, Yu XM, Jiang B, et al. Zhongguo Zhong Yao Za Zhi. 2021;46(17):4438-4445. [3]. Liger F, Popowycz F, Besson T, Picot L, Galmarini CM, Joseph B. Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres. Bioorg Med Chem. 2007;15(16):5615-5619.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

References

[1]. Wang Y, Li J, Han X, et al. Identification of Clausine E as an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. J Mol Recognit. 2019;32(10):e2800.

[2]. Guo JM, Yu XM, Jiang B, et al. Zhongguo Zhong Yao Za Zhi. 2021;46(17):4438-4445.

[3]. Liger F, Popowycz F, Besson T, Picot L, Galmarini CM, Joseph B. Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres. Bioorg Med Chem. 2007;15(16):5615-5619.

Molecular Formula	C₁₄H₁₁NO₃
Molecular Weight	241.24
Exact Mass	241.07400
PSA	62.32000
LogP	2.81330

Hazard Codes	Xi

methyl 1-hydroxy-9H-carbazole-3-carboxylate

1-Hydroxy-9H-carbazole-3-carboxylic acid methyl ester

clauszoline I

clauszoline-I

clausine-E

clausine E

Use of clausine E

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clausine E Biological Activity

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