110225-59-7

110225-59-7 structure

Name: Guanfu base I
Chemical Name: acorine
CAS Number: 110225-59-7
Molecular Formula: C₂₂H₂₉NO₅
Molecular Weight: 387.46900
Catalog: Signaling Pathways Others Others
Create Date: 2018-06-20 18:35:49
Modify Date: 2024-01-30 12:08:54
Guanfu base I (Acorine) is an active metabolite of Guanfu base A, isolated from Aconitum coreanum, and has a potent anti-arrhythmic effect[1].

Name	acorine

Description	Guanfu base I (Acorine) is an active metabolite of Guanfu base A, isolated from Aconitum coreanum, and has a potent anti-arrhythmic effect[1].
Related Catalog	Signaling Pathways >> Others >> Others
In Vivo	The pharmacokinetics of Guanfu base I in Sprague-Dawley rats is examined. The method is linear in the 0.05-20 μg/mL concentration range. The recovery of Guanfu base I is more than 80%. The intraday and interday precision, expressed as the relative standard deviation, is generally good. After intravenous injection dosing, plasma Guanfu base I concentration declined in a bi-phasic manner with a terminal elimination half-life of 2.49 hours. The total plasma clearance value is 1.46 L/h/kg. After oral dosing, the plasma Guanfu base I concentration reached a maximum within 0.5 hour. The absolute bioavailability of Guanfu base I is 71.31%[1].
References	[1]. Li X, et al. Pharmacokinetics of guanfu base I, an active metabolite of guanfu base A, in rats. Biol Pharm Bull. 2005 Aug;28(8):1363-5.