13258-85-0

13258-85-0 structure

Name: 10-Vinyl-19-norpregn-4-ene-3,20-dione
Chemical Name: Org OD 02-0
CAS Number: 13258-85-0
Molecular Formula: C₂₂H₃₀O₂
Molecular Weight: 326.47200
Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
Create Date: 2018-05-31 03:25:38
Modify Date: 2024-01-08 23:18:25
Org OD 02-0 (10-Ethenyl-19-norprogesterone) is a membrane progesterone receptor α (mPRα)-specific agonist (IC50: 33.9 nM). Org OD 02-0 activates MAPK activity. Org OD 02-0 inhibits prolactin (PRL) secretion in the pituitary[1][2].

Name	Org OD 02-0
Synonyms	19-Methylen-progestron (8S,9S,10S,13S,14S,17S)-17-Acetyl-13-methyl-10-vinyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 10-ethenyl-19-norprogesterone

Description	Org OD 02-0 (10-Ethenyl-19-norprogesterone) is a membrane progesterone receptor α (mPRα)-specific agonist (IC50: 33.9 nM). Org OD 02-0 activates MAPK activity. Org OD 02-0 inhibits prolactin (PRL) secretion in the pituitary[1][2].
Related Catalog	Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Endocrinology Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Target	33.9 nM (mPRα)[1]
References	[1]. Kelder J, et al. Comparison between steroid binding to membrane progesterone receptor alpha (mPRalpha) and to nuclear progesterone receptor: correlation with physicochemical properties assessed by comparative molecular field analysis and identification of mPRalpha-specific agonists. Steroids. 2010 Apr;75(4-5):314-22. [2]. Camilletti MA, et al. Participation of membrane progesterone receptor α in the inhibitory effect of progesterone on prolactin secretion. J Neuroendocrinol. 2018 Sep;30(9):e12614.