152831-00-0

152831-00-0 structure

Name: 6-Hydroxybenzbromarone
Chemical Name: 6-Hydroxybenzbromarone
CAS Number: 152831-00-0
Molecular Formula: C₁₇H₁₂Br₂O₄
Molecular Weight: 440.08300
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2018-06-20 07:04:41
Modify Date: 2024-01-14 22:53:52
6-Hydroxybenzbromarone is the major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM. 6-Hydroxybenzbromarone is an angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting[1].

Name	6-Hydroxybenzbromarone
Synonyms	6-hydroxy-benzbromarone (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-benzofuran-3-yl)methanone 2-ethyl-3-(3,5-dibromo-4-hydroxybenzoyl)-6-hydroxybenzofuran 6-hydroxybenzbromarone 6-OH benzbromarone 2-ethyl-6-hydroxy-3-(3',5'-dibromo-4'-hydroxy-benzoyl)-benzofuran

Description	6-Hydroxybenzbromarone is the major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM. 6-Hydroxybenzbromarone is an angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Target	IC50: 21.5 μM (EYA3); metabolite[1]
In Vitro	6-Hydroxybenzbromarone (7.5 μM; 72 hours) shows over 50% reduction in cell proliferation. Meanwhile, treatment with BBR and BZ also reduces cell viability, but none of the other compounds tested has a negative impact on cell viability or proliferation[1]. 6-Hydroxybenzbromarone (7.5 μM; 1-20 hours) has inhibitory affects EC migration tubulogenesis of HUVECs. However, the effect of 6OH-BBR on tube formation is attenuated in the presence of high concentrations of fetal bovine serum (FBS), likely reflecting non-specific protein binding[1]. Cell Proliferation Assay[1] Cell Line: HUVEC cells Concentration: 7.5 μM Incubation Time: 72 hours Result: Inhibited HUVEC cells proliferation.
References	[1]. Pandey RN, et al. Structure-activity relationships of benzbromarone metabolites and derivatives as EYA inhibitory anti-angiogenic agents.PLoS One. 2013 Dec 18;8(12):e84582.