6-Hydroxybenzbromarone
Modify Date: 2024-01-14 22:53:52
6-Hydroxybenzbromarone structure
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Common Name | 6-Hydroxybenzbromarone | ||
|---|---|---|---|---|
| CAS Number | 152831-00-0 | Molecular Weight | 440.08300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H12Br2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 6-Hydroxybenzbromarone6-Hydroxybenzbromarone is the major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM. 6-Hydroxybenzbromarone is an angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting[1]. |
| Name | 6-Hydroxybenzbromarone |
|---|---|
| Synonym | More Synonyms |
| Description | 6-Hydroxybenzbromarone is the major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM. 6-Hydroxybenzbromarone is an angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting[1]. |
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| Related Catalog | |
| Target |
IC50: 21.5 μM (EYA3); metabolite[1] |
| In Vitro | 6-Hydroxybenzbromarone (7.5 μM; 72 hours) shows over 50% reduction in cell proliferation. Meanwhile, treatment with BBR and BZ also reduces cell viability, but none of the other compounds tested has a negative impact on cell viability or proliferation[1]. 6-Hydroxybenzbromarone (7.5 μM; 1-20 hours) has inhibitory affects EC migration tubulogenesis of HUVECs. However, the effect of 6OH-BBR on tube formation is attenuated in the presence of high concentrations of fetal bovine serum (FBS), likely reflecting non-specific protein binding[1]. Cell Proliferation Assay[1] Cell Line: HUVEC cells Concentration: 7.5 μM Incubation Time: 72 hours Result: Inhibited HUVEC cells proliferation. |
| References |
| Molecular Formula | C17H12Br2O4 |
|---|---|
| Molecular Weight | 440.08300 |
| Exact Mass | 437.91000 |
| PSA | 70.67000 |
| LogP | 5.16240 |
| 6-hydroxy-benzbromarone |
| (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-benzofuran-3-yl)methanone |
| 2-ethyl-3-(3,5-dibromo-4-hydroxybenzoyl)-6-hydroxybenzofuran |
| 6-hydroxybenzbromarone |
| 6-OH benzbromarone |
| 2-ethyl-6-hydroxy-3-(3',5'-dibromo-4'-hydroxy-benzoyl)-benzofuran |