11041-12-6
11041-12-6 structure
- Name: Colestyramine
- Chemical Name: cholestyramine resin
- CAS Number: 11041-12-6
- Molecular Formula: C21H30ClN
- Molecular Weight: 331.923
- Catalog: API Circulatory system medication Regulating blood lipids
- Create Date: 2018-07-09 19:20:18
- Modify Date: 2024-01-02 16:34:56
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Colestyramine (Cholestyramine) is a bile acid binding resin and can inhibit intestinal bile acid absorption which results in the increasing bile acid synthesis from cholesterol.
| Name | cholestyramine resin |
|---|---|
| Synonyms |
colestyramin
CHOLESTYRAMINE RESIN 4-[3-(4-Ethylphenyl)butyl]-N,N,N-trimethylanilinium chloride Benzenaminium, 4-[3-(4-ethylphenyl)butyl]-N,N,N-trimethyl-, chloride (1:1) cholestyraminechloride cuemid polystyrenebenzyltrimethylaminoniumchloride quantalan MFCD00130784 CHOLESTYRAMINE EINECS 234-270-8 DOWEX 1 X 2 CL-FORM Colestyramine |
| Description | Colestyramine (Cholestyramine) is a bile acid binding resin and can inhibit intestinal bile acid absorption which results in the increasing bile acid synthesis from cholesterol. |
|---|---|
| Related Catalog | |
| In Vivo | Colestyramine (Cholestyramine) is a bile acid binding resin and can inhibit intestinal bile acid absorption which results in the increasing bile acid synthesis from cholesterol[1]. Results reveal that GSPE treatment alone, and co-administration with Colestyramine (CHY), regulate BA, cholesterol and TG metabolism differently compare to Colestyramine (CHY) administration alone. Notably, GSPE decreases intestinal apical sodium-dependent bile acid transporter (Asbt) gene expression, while Colestyramine (CHY) significantly induces expression. Administration with GSPE or Colestyramine (CHY) robustly induces hepatic BA biosynthetic gene expression, especially cholesterol 7α-hydroxylase (Cyp7a1), compare to control, while co-administration further enhances expression. Treatment with Colestyramine (CHY) induces both intestinal and hepatic cholesterologenic gene expression, while co-administration with GSPE attenuates the Colestyramine (CHY)-inducing increase in the liver but not in the intestine. Colestyramine (CHY) also induces hepatic lipogenic gene expression, which is attenuated by co-administration with GSPE[2]. |
| Animal Admin | Mice are purchased at 7 weeks of age and allowed to acclimate for one week. At 8-weeks of age the mice are given either a control or a 2% Colestyramine (cholestyramine)-supplementing diet for 4 weeks (n=18 per group). Body weight for each mouse is recorded weekly. After 4 weeks, the mice in each group are randomly assigned to one of two treatment groups and orally gavaged with either vehicle (water) or GSPE (250 mg/kg) and terminated 14 hours later (n=9 per experimental group). The four treatment groups are as follows: 1. CON: Control diet for 4 weeks following by oral gavage with vehicle (water) for 14 hrs; 2. GSPE: Control diet for 4 weeks following by oral gavage with 250 mg/kg GSPE for 14 hrs; 3.CHY Colestyramine (cholestyramine): 2% Colestyramine (cholestyramine)-supplementing diet for 4 weeks following by oral gavage with vehicle for 14 hrs; and 4. CHY Colestyramine (cholestyramine)+GSPE: 2% cholestyramine-supplementing diet for 4 weeks following by oral gavage with 250 mg/kg GSPE for 14 hrs. Blood is collected from the orbital plexus under isoflurane anesthesia, and intestines and livers are snap-frozen in liquid nitrogen and stored at -80°C until use. At the start of the 14 hr experiment mice are placed into clean cages, and feces are manually collected at the end of the study[2]. |
| References |
| Molecular Formula | C21H30ClN |
|---|---|
| Molecular Weight | 331.923 |
| Exact Mass | 331.206665 |
| Water Solubility | Insoluble in water, in methylene chloride and in ethanol (96 per cent). |